YAP在胃癌进展中的作用机制及临床意义

doi:10.3760/cma.j.cn371439-20220627-00135

摘要/Abstract

摘要：

胃癌是我国高发的恶性肿瘤之一。随着肿瘤分子生物学的研究不断深入，分子靶向治疗彰显优势，免疫治疗也备受关注。Yes相关蛋白（YAP）是Hippo通路中起主要作用的效应蛋白，在与细胞核中的转录因子结合后可对细胞的生长起调控作用。近年来较多研究表明YAP的高表达与胃癌的发生、发展和转移密切相关，YAP可能是化疗耐药性的重要靶点，对其深入研究可以为临床治疗提供参考。

关键词: 胃肿瘤, Yes相关蛋白, Hippo通路

Abstract:

Gastric cancer is one of the common malignant tumors with a high incidence in China. With the deepening of the research on tumor molecular biology， molecular targeted therapy has shown its advantages， and immunotherapy has attracted much attention. Yes-associated protein （YAP） is an effector protein that plays a major role in Hippo pathway， and it can regulate the growth of cells after binding with transcription factors in the nucleus. In recent years， many studies have shown that the high expression of YAP is closely related to the occurrence， development and metastasis of gastric cancer， and may be an important target of chemotherapy resistance. The further study can provide reference for clinical treatment.

Key words: Gastric neoplasms, Yes-associated protein, Hippo pathway

蔡甲慧, 荣光宏. YAP在胃癌进展中的作用机制及临床意义[J]. 国际肿瘤学杂志, 2022, 49(11): 687-691.

Cai Jiahui, Rong Guanghong. Mechanism and clinical significance of YAP in the progression of gastric cancer[J]. Journal of International Oncology, 2022, 49(11): 687-691.

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