国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (9): 553-557.doi: 10.3760/cma.j.issn.1673-422X.2019.09.009

• 综述 • 上一篇    下一篇

非编码RNA在胃癌中的研究进展

肖唱，辛彦   

  1. 中国医科大学附属第一医院肿瘤研究所胃肠肿瘤病理研究室 普通外科研究所肿瘤病理研究室，沈阳110001
  • 收稿日期:2019-07-11 出版日期:2019-09-08 发布日期:2019-09-08
  • 通讯作者: 辛彦 E-mail:yxin@cmu.edu.cn
  • 基金资助:
    国家自然科学基金（81071650）；辽宁省科学技术计划（2013225585）

Research progress of non-coding RNA in gastric cancer

Xiao Chang, Xin Yan   

  1. Laboratory of Gastrointestinal Tumor Pathology, Cancer Institute ＆ Laboratory of Tumor Pathology, General Surgery Institute, First Affiliated Hospital of China Medical University, Shenyang 110001, China
  • Received:2019-07-11 Online:2019-09-08 Published:2019-09-08
  • Contact: Xin Yan E-mail:yxin@cmu.edu.cn
  • Supported by:
    National Natural Science Foundation of China (81071650); Science and Technology Project of Liaoning Province of China (2013225585)

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摘要： 非编码RNA是一类无蛋白质编码功能的RNA，在肿瘤发生和发展过程中发挥重要作用。研究发现长非编码RNA、环状RNA、假基因在胃癌的发生、发展过程中发挥促癌和抑癌作用，并且可通过内源竞争RNA机制参与调控胃癌细胞增殖、凋亡、侵袭和转移等各类恶性生物学行为。另外研究还发现小干扰RNA、与Piwi蛋白相作用的RNA也可能与胃癌的发生发展有关。

关键词: 胃肿瘤, 非编码RNA

Abstract: Non-coding RNA is a kind of RNA, without protein coding function, which plays an important role in the occurrence and development of tumors. Studies show that long noncoding RNA, circRNA and pseudogenes play tumorpromoting and antitumor effects in the occurrence and development of gastric cancer, which can regulate all kinds of malignant biological behaviors of gastric cancer such as cell proliferation, apoptosis, invasion and metastasis through internal competitive RNA (ceRNA) mechanism. In addition, studies show that small interfering RNA and Piwiinteracting RNA may also be related to the occurrence and development of gastric cancer.

Key words: Stomach neoplasms, Non-coding RNA