免疫检查点抑制剂在晚期非小细胞肺癌综合治疗中的应用

doi:10.3760/cma.j.issn.1673-422X.2019.08.012

摘要/Abstract

摘要： 近年来，免疫治疗已成为晚期非小细胞肺癌（NSCLC）治疗的重要组成部分。肿瘤细胞可介导多种免疫逃逸机制躲避机体免疫系统的杀伤，其中程序性死亡蛋白-1及其配体（PD-1/PD-L1）介导的免疫逃逸发挥着关键作用。目前化疗、放疗、分子靶向治疗在晚期NSCLC的治疗中有一定的局限性。近期研究发现PD-1/PD-L1抑制剂与以上治疗综合应用具有一定的协同作用，可增强抗肿瘤效果，进一步延长患者生存期。免疫治疗改变了NSCLC治疗模式，也对受益人群的筛选、治疗相关不良反应的处理带来挑战。总结免疫检查点抑制剂在晚期NSCLC综合治疗中的研究进展，可为NSCLC的最佳治疗方式提供参考依据。

关键词: 肺肿瘤, 免疫治疗, PD-1/PD-L1, 综合治疗

Abstract: In recent years, immunotherapy has become an important part of the treatment for advanced non-small cell lung cancer (NSCLC). Tumor cells can escape from the body′s immune system by mediating various immune escape mechanisms, among which programmed death-1/programmed death ligand-1 (PD-1/PD-L1) mediated immune escape plays an important role. Currently, chemotherapy, radiotherapy and molecular targeted therapy have certain limitations in the treatment of advanced NSCLC. Recent studies have found that the combined application of PD-1/PD-L1 inhibitor and other treatment methods has certain synergistic effect, thus enhances the anti-tumor effect and further prolongs the survival of patients. Immunotherapy brings not only changes in the treatment patterns of NSCLC, but also challenges in the screening of target population and the management of treatment-related adverse reactions. Summarizing the research progress on immune checkpoint inhibitors in the comprehensive treatment of advanced NSCLC can provide reference for the best treatment of NSCLC.

Key words: Lung neoplasms, Immunotherapy, PD-1/PD-L1, Comprehensive therapy

白馨雅, 张金梦, 孙洋, 安永恒. 免疫检查点抑制剂在晚期非小细胞肺癌综合治疗中的应用[J]. 国际肿瘤学杂志, 2019, 46(8): 500-504.

Bai Xinya, Zhang jinmeng, Sun Yang, An Yongheng . Application of immune checkpoint inhibitors in the comprehensive treatment of advanced non-small cell lung cancer[J]. Journal of International Oncology, 2019, 46(8): 500-504.

参考文献

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