纳武单抗在晚期非小细胞肺癌治疗中的应用

doi:10.3760/cma.j.issn.1673-422X.2019.05.009

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (5): 295-298.doi: 10.3760/cma.j.issn.1673-422X.2019.05.009

纳武单抗在晚期非小细胞肺癌治疗中的应用

刘冬祺¹，陈润泽²，刘禹含¹，周欢¹

¹大连医科大学附属第二医院肿瘤三科116000； ²大连理工大学莱斯特国际学院，盘锦124221

收稿日期:2019-01-21 出版日期:2019-05-08 发布日期:2019-06-14
通讯作者: 周欢 E-mail:zhouhuan8103@126.com
基金资助:
辽宁省自然科学基金（2015020656）

Application of the Nivolumab in the treatment of advanced non-small cell lung cancer

Liu Dongqi¹, Chen Runze², Liu Yuhan¹, Zhou huan¹

¹Third Department of Oncology, Second Hospital of Dalian Medical University, Dalian 116000, China; ²Leicester International Institute, Dalian University of Technology, Panjin 124221, China

Received:2019-01-21 Online:2019-05-08 Published:2019-06-14
Contact: Zhou Huan E-mail:zhouhuan8103@126.com
Supported by:
National Science Foundation of Liaoning Province of China (2015020656)

摘要/Abstract

摘要： 我国肺癌发病率及死亡率居全部恶性肿瘤首位，与非小细胞肺癌（NSCLC）相关的治疗研究如靶向治疗、免疫治疗也是近年来的研究热点。纳武单抗是第1个进入临床试验的程序性死亡蛋白-1抑制剂，也是中国首个获批上市的肿瘤免疫治疗药物。2018年6月，纳武单抗注射液在国内上市，用于晚期NSCLC患者的二线治疗，开启了我国肺癌治疗的新时代。对纳武单抗治疗NSCLC相关的临床研究进行回顾分析，归纳其用法、用量、主要不良反应，将为临床应用提供帮助，为患者带来更大的益处。

关键词: 癌, 非小细胞肺, 免疫治疗, 纳武单抗

Abstract: Lung cancer has the highest morbidity and mortality among malignant tumors in our country. The treatment researches related to nonsmall cell lung cancer (NSCLC) such as targeted therapy and immunotherapy are the research hotspots in recent years. Nivolumab is the first programmed death-1 (PD-1) inhibitor which is allowed to enter clinical trials, and it is also the first approved drug for tumor immunotherapy in China. In June 2018, Nivolumab injection was marketed in China, and it was used in the secondline treatment for the patients with advanced NSCLC, opened up a new era of the lung cancer treatment in our country. Review the clinical research related to the Nivolumab and NSCLC, summarizing usage, dosage, adverse reactions, will provide a help for clinical application, bring more benefits for patients at the same time.

Key words: Carcinoma, non-small-cell lung, Immunotherapy, Nivolumab

刘冬祺，陈润泽，刘禹含，周欢. 纳武单抗在晚期非小细胞肺癌治疗中的应用[J]. 国际肿瘤学杂志, 2019, 46(5): 295-298.

Liu Dongqi, Chen Runze, Liu Yuhan, Zhou huan. Application of the Nivolumab in the treatment of advanced non-small cell lung cancer[J]. Journal of International Oncology, 2019, 46(5): 295-298.

参考文献

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纳武单抗在晚期非小细胞肺癌治疗中的应用

Application of the Nivolumab in the treatment of advanced non-small cell lung cancer

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