关键词: 脑膜瘤, 遗传学, 基因表达调控, 表型, 生物学标记

Abstract: Atypical and malignant meningiomas are characterized by high invasiveness and local recurrence. Traditional treatments such as surgery, radiotherapy and chemotherapy have limited effects. Recently, with the further study of the pathogenesis of meningioma and the development of molecular biology techniques, some new biomarkers have been found to play important roles in development and malignant progression of meningioma. Several genetic and epigenetic factors have been identified as contributing to the malignant progression of meningioma. Genetic factors include multiple phenotypic changes such as abnormal cell proliferation, increased cell invasiveness, angiogenesis, apoptosis inhibition, and changes in telomerase activity. And the discovery of biomarkers provides references for early diagnosis, molecular targeted therapy and prognosis assessment of highgrade meningiomas.

Key words: Meningioma, Genetics, Gene expression regulation, Phenotype, Biological markers