小眼畸形相关转录因子在黑色素瘤转移中的作用

doi:10.3760/cma.j.issn.1673-422X.2017.04.010

摘要/Abstract

摘要： 小眼畸形相关转录因子（MITF）一直是近几年黑色素瘤细胞研究中的热点。异常表达的MITF与黑色素瘤的发生和转移密切相关，且MITF低表达能促进黑色素瘤细胞的侵袭。研究MITF及与其相关的分子和信号通路的调节关系，将进一步加深对恶性黑色素瘤转移分子机制的理解，为开发新的分子靶向药物提供帮助。

关键词: 肿瘤转移, 小眼畸形相关转录因子, 黑色素瘤

Abstract: In recent years, the function of microphthalmiaassociated transcription factor (MITF) is a hot field in melanoma. The abnormal expression of MITF is closely related to the occurrence and metastasis of melanoma. In addition, the down expression of MITF promotes its invasion. Studying the regulation of MITF and its related molecules and signaling pathways will let us further understand the molecule mechanism of malignant melanoma metastasis and provide help to exploit novel molecular targeted drug.

Key words: Neoplasms metastasis, Microphthalmia-associated transcription factor, Melanoma

贺艳,帖君,唐郡. 小眼畸形相关转录因子在黑色素瘤转移中的作用[J]. 国际肿瘤学杂志, 2017, 44(4): 281-283.

He Yan, Tie Jun, Tang Jun. Role of microphthalmia-associated transcription factor in melanoma metastasis[J]. Journal of International Oncology, 2017, 44(4): 281-283.

参考文献

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