UGT在恶性肿瘤代谢中的作用及其临床意义

doi:10.3760/cma.j.cn371439-20250704-00026

摘要/Abstract

摘要：

尿苷二磷酸葡萄糖醛酸转移酶（UGT）是Ⅱ相代谢关键限速酶，可介导内源性化合物、外源性化合物的葡萄糖醛酸化，调控其清除与信号转导。UGT在乳腺癌、肺癌、前列腺癌及慢性淋巴细胞白血病中通过调控雌-雄激素及其相应受体、糖酵解途径及相关通路，驱动肿瘤发生发展及化疗耐药。进一步探讨UGT在多种恶性肿瘤代谢中的双重作用及其临床意义，可为肿瘤诊断、预后评估和精准用药提供新的生物标志物和治疗靶点。

关键词: 肿瘤, 尿苷二磷酸葡糖醛酸, 代谢解毒，Ⅱ期

Abstract:

Uridine diphosphate-glucuronosyltransferases （UGTs） are key rate-limiting phase Ⅱ enzymes that mediate the glucuronidation of endobiotics and xenobiotics，thereby governing the clearance and signal transduction. UGTs drive oncogenesis，progression and chemoresistance in breast cancer，lung cancer，prostate cancer，and chronic lymphocytic leukemia by regulating estrogen/androgen levels and related receptors，as well as glycolytic and associated signaling pathways. Further exploration of the dual roles of UGTs in various cancer metabolism and the clinical significance will provide novel biomarkers and therapeutic targets for tumor diagnosis，prognosis assessment and precise medication.

Key words: Neoplasms, Uridine diphosphate glucuronic acid, Metabolic detoxication，phase Ⅱ

乔锦阳, 李慧, 冯勤梅. UGT在恶性肿瘤代谢中的作用及其临床意义[J]. 国际肿瘤学杂志, 2026, 53(3): 163-166.

Qiao Jinyang, Li Hui, Feng Qinmei. Role of UGT in metabolism of malignant tumors and clinical significance[J]. Journal of International Oncology, 2026, 53(3): 163-166.

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