长非编码RNA DLEU1在恶性肿瘤中的研究进展

doi:10.3760/cma.j.cn371439-20250523-00121

摘要/Abstract

摘要：

长非编码RNA DLEU1作为泛癌研究的新型关键分子，其在调控恶性肿瘤的发生、发展中可能扮演着至关重要的角色。尽管DLEU1在学术领域的研究有限，但近年来有研究初步证实，DLEU1在多种恶性肿瘤中表达异常，并可通过竞争性内源RNA机制、表观遗传调控及转录反馈环路等途径调控肿瘤细胞的恶性表型，包括增殖、迁移、浸润以及化疗抗性等，并与肿瘤不良预后密切相关，此外，其在外泌体中的特异性富集现象提示其可能具有潜在的诊断价值。系统性分析和探讨DLEU1在各类恶性肿瘤中的表达调控与作用机制，可深入解析DLEU1在恶性肿瘤中的时空异质性、靶向治疗策略及与微环境相互作用等生物学机制，为基于非编码RNA的肿瘤精准治疗与基础研究应用等方面提供借鉴与参考。

关键词: RNA，长链非编码, 生物标记，肿瘤, 表观基因组学, 肿瘤异质性, 竞争性内源RNA

Abstract:

Long non-coding RNA DLEU1 has emerged as a novel key molecule in pan-cancer research， potentially playing a critical role in regulating the occurrence and progression of malignant tumors. Although studies on DLEU1 remain limited， recent researches have confirmed its aberrant expression in various malignancies. DLEU1 can regulate the malignant phenotype of tumor cells through competitive endogenous RNA mechanisms， epigenetic regulation， and transcriptional feedback loops， including proliferation， migration， invasion， and chemoresistance， which are closely associated with poor prognosis. Additionally， its enrichment in exosomes suggests its potential as a diagnostic biomarker. Systematic analysis and exploration of the expression regulation and mechanism of action of DLEU1 in various malignant tumors can deeply understand the biological mechanisms such as the spatio-temporal heterogeneity， targeted treatment strategies， and interaction with the microenvironment of DLEU1 in malignant tumors， providing reference and guidance for precise tumor treatment and basic research applications based on non-coding RNA.

Key words: RNA， long noncoding, Biomarkers， tumor, Epigenomics, Tumor heterogeneity, Competing endogenous RNA

孙明珠, 刘彦权, 孙蕾, 唐焕文. 长非编码RNA DLEU1在恶性肿瘤中的研究进展[J]. 国际肿瘤学杂志, 2025, 52(11): 708-713.

Sun Mingzhu, Liu Yanquan, Sun Lei, Tang Huanwen. Research progress of long non-coding RNA DLEU1 in malignant tumors[J]. Journal of International Oncology, 2025, 52(11): 708-713.

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