HPV阳性口咽癌降级治疗的研究进展

doi:10.3760/cma.j.cn371439-20210428-00041

摘要/Abstract

摘要：

既往研究表明,人乳头状瘤病毒（HPV）阳性口咽癌患者的预后显著优于HPV阴性患者。但在标准治疗模式下,口咽癌患者严重不良反应发生率高,影响了治疗的可持续性。目前,国内外研究表明降级治疗是HPV相关性口咽癌未来治疗的趋势,该类患者的降级治疗模式也是目前研究的热点。降低化疗强度、降低放疗强度、通过联合治疗模式降低放化疗剂量等为HPV相关性口咽癌的降级治疗提供了进一步研究的方向。

关键词: 口咽肿瘤, 人乳头瘤病毒, 降级治疗, 适用人群

Abstract:

Previous studies have shown that patients with human papilloma virus（HPV）-positive oropharyngeal cancer have a significantly better prognosis than patients with HPV-negative oropharyngeal cancer. However, the high incidence of severe adverse reactions in patients with oropharyngeal cancer under the standard treatment mode affects the sustainability of treatment. At present, internal and overseas studies have indicated that step-down therapy is the trend of future treatment for HPV-associated oropharyngeal cancer, and the step-down therapy mode of these patients is also a hotspot of current research. Reducing the intensity of chemotherapy, reducing the intensity of radiotherapy, and reducing the dose of radiotherapy and chemotherapy through the combination therapy mode provide further research directions for the step-down therapy of HPV-associated oropharyngeal cancer.

Key words: Oropharyngeal neoplasms, Human papilloma virus, Step-down therapy, Indicated population

王琪, 王澜, 韩春. HPV阳性口咽癌降级治疗的研究进展[J]. 国际肿瘤学杂志, 2022, 49(4): 229-232.

Wang Qi, Wang Lan, Han Chun. Research progress on downgrading therapy for HPV positive oropharyngeal carcinoma[J]. Journal of International Oncology, 2022, 49(4): 229-232.

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