国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (10): 737-740.doi: 10.3760/cma.j.issn.1673-422X.2016.10.004

• 论著 • 上一篇    下一篇

非小细胞肺癌患者人乳头瘤病毒感染分析

 闫滢,何义富,李明   

  1. 230031 合肥，安徽省立医院西区（安徽省肿瘤医院）肿瘤内一科（闫滢、何义富），检验科（李明）
  • 出版日期:2016-10-08 发布日期:2016-09-07
  • 通讯作者: 李明 E-mail:liming19831002@163.com
  • 基金资助:

    安徽省自然科学基金（1308085QH144）

Analysis of human papillomavirus infection in nonsmall cell lung cancer

Yan Ying, He Yifu, Li Ming   

  1. First Department of Medical Oncology, Western Branch of Anhui Provincial Hospital (Anhui Provincial Cancer Hospital), Hefei 230031, China
  • Online:2016-10-08 Published:2016-09-07
  • Contact: Li Ming E-mail:liming19831002@163.com
  • Supported by:

    Natural Science Foundation of Anhui Province of China (1308085QH144)

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摘要： 目的研究非小细胞肺癌（NSCLC）患者人乳头瘤病毒（HPV）感染情况，探讨NSCLC HPV感染与临床病理特征的相关性。方法收集156例病理确诊的NSCLC石蜡组织标本，采用Luminex液相芯片技术对所有标本进行HPV基因分型。收集患者临床病理资料，分析HPV感染与临床病理特征的相关性。结果156例NSCLC患者组织中HPV感染率为25.6%（40/156），其中高危型37例，包括HPV16、18、33、58亚型。HPV感染与患者性别（χ2=4.387，P=0.036）、吸烟史（χ2=8.130，P=0.004）、组织类型（χ2=4.075，P=0.044）和淋巴结转移（χ2=7.082，P=0.008）相关；与患者年龄（χ2=0.013，P=0.910）、分化程度（χ2=1.727，P=0.189）、临床分期（χ2=0.179，P=0.672）、远处转移（χ2=3.012，P=0.083）无关。Logistic回归模型分析发现患者淋巴结是否转移是HPV感染的独立影响因子（OR=0.384，95%CI为0.153～0.967，P=0.042）；而患者性别（OR=1.402，95%CI为0.522～3.769，P=0.503）、吸烟史（OR=0.506，95%CI为0.194～1.322，P=0.506）、组织类型（OR=0.393，95%CI为0.133～0.161，P=0.091）不是HPV感染的独立影响因子。结论我国部分NSCLC患者存在HPV感染，HPV感染可能与肺癌的发生发展密切相关。

关键词: 癌, 非小细胞肺, 人乳头瘤病毒, 液相芯片技术

Abstract: ObjectiveTo detect the infection of human papillomavirus (HPV) in patients with nonsmall cell lung cancer (NSCLC) and explore the relationship between HPV infection and clinicopathological features. MethodsHPV detection and genotyping in 156 cases of NSCLC were performed using a new liquid chip based on Luminex. Patient clinical characteristics were also recorded, and the relationship between HPV infection and clinicopathological features was studied. ResultsOf the 156 tumorDNA samples tested, 40 (25.6%) cases showed presence of HPVDNA, of which 37 cases were of a highrisk HPV type (16, 18, 33, 58). The differences were statistically significant between the HPVpositive and HPVnegative groups in gender (χ2=4.387, P=0.036), smoking (χ2=8.130, P=0.004), histologic type (χ2=4.075, P=0.044) and lymph node metastasis (χ2=7.082, P=0.008). The differences were not statistically significant between the HPVpositive and HPVnegative groups in age (χ2=0.013, P=0.910), differentiated degree (χ2=1.727, P=0.189), clinical stages (χ2=0.179, P=0.672), distant metastasis (χ2=3.012, P=0.083). Logistic regression analysis revealed that lymph node metastasis alone was an independent predictive factor of HPV infection in NSCLC (OR=0.384, 95%CI: 0.1530.967, P=0.042), and gender (OR=1.402, 95%CI: 0.5223.769, P=0.503), smoking (OR=0.506, 95%CI: 0.1941.322, P=0.506), histologic type (OR=0.393, 95%CI: 0.1330.161, P=0.091) were not independent predictive factors of HPV infection.ConclusionThe infection of HPV presents in part of Chinese NSCLC patients, and HPV infection may be connected with occurrence and development of lung cancer.

Key words: Carcinoma, nonsmall cell lung cancer, Human, papillomavirus, Luminex technology