国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (2): 102-104.doi: 10.3760/cma.j.issn.1673-422X.2019.02.009

• 综述 • 上一篇    下一篇

p53基因在非小细胞肺癌中的表达及临床意义

温洁,陈绍水   

  1. 滨州医学院附属医院肿瘤科256600
  • 出版日期:2019-02-08 发布日期:2019-04-03
  • 通讯作者: 陈绍水，Email: byfychenss@126.com E-mail:byfychenss@126.com

Expression and clinical significance of p53 gene of non-small cell lung cancer

Wen Jie, Chen Shaoshui   

  1. Department of Oncology, Affiliated Hospital of Binzhou Medical University, Binzhou 256600, China
  • Online:2019-02-08 Published:2019-04-03
  • Contact: Chen Shaoshui, Email: byfychenss@126.com E-mail:byfychenss@126.com

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摘要： 非小细胞肺癌的发生、发展是多因素相互作用的复杂过程，在此过程中p53基因调控着细胞的正常生长，而突变后的p53基因可导致非小细胞肺癌的发生、促进肿瘤的转移、诱导化疗耐药、致使患者预后不良。恢复正常p53基因的表达对非小细胞肺癌的治疗尤其重要，近年来p53基因治疗方面研究的飞速发展为非小细胞肺癌的治疗开辟了新的途径。

关键词: 癌, 非小细胞肺, 基因, p53, 治疗应用

Abstract: The development of nonsmall cell lung cancer (NSCLC) is a complex process which referring to multifactor interaction. In this process, p53 gene regulates the normal growth of cells, but p53 gene after mutation can induce the occurrence of NSCLC, promote tumor distant metastasis, induce chemotherapy resistance, and cause poor prognosis of patients. Therefore, the restoration of normal expression of p53 gene is very significant for the treatment of NSCLC. In recent years, the rapid progress of p53 gene therapy has opened up a new way for the treatment of NSCLC.

Key words: Carcinoma, non-small-cell lung, Genes, p53, Therapeutic uses