国际肿瘤学杂志

国际肿瘤学杂志 ›› 2017, Vol. 44 ›› Issue (2): 139-141.doi: 10.3760/cma.j.issn.1673422X.2017.02.016

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Wnt/β-catenin信号转导通路影响神经胶质瘤侵袭的机制

刘静, 王小刚, 郭庚, 赵元立   

  1. 030001 太原，山西医科大学第一医院神经外科（刘静、王小刚、郭庚）；首都医科大学附属北京天坛医院神经外科（赵元立）
  • 出版日期:2017-02-08 发布日期:2017-01-04
  • 通讯作者: 郭庚，Email： guogeng973@163.com E-mail:guogeng973@163.com
  • 基金资助:

     国家自然科学基金（81201991）；中国博士后科学基金（2015M571068、2016T90115）；北京市博士后工作经费资助项目（2015ZZ-56、2016ZZ-43）；山西省自然科学基金（201601D011127）；山西省高等学校创新人才支持计划（晋教科［2013］8号）；山西省卫生厅科研课题（201301066）

The mechanism of Wnt/β-catenin signaling pathway in glioma invasion

Liu Jing, Wang Xiaogang, Guo Geng, Zhao Yuanli   

  1. Department of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Online:2017-02-08 Published:2017-01-04
  • Contact: Guo Geng E-mail:guogeng973@163.com
  • Supported by:

    National Natural Science Foundation of China (81201991); China Postdoctoral Science Foundation (2015M571068, 2016T90115); Project Supported by Beijing Postdoctoral Research Foundation (2015ZZ-56, 2016ZZ-43); Natural Science Foundation of Shanxi Province of China (201601D011127); Program for the Outstanding Innovative Teams of Higher Learning Institutions of Shanxi Province(2013-8); Scientific Research Subject of Shanxi Provincial Health Department (201301066)

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摘要： 神经胶质瘤的侵袭是一个多步骤、多因素参与的复杂过程，主要包括抑制肿瘤细胞黏附，降解细胞外基质，促进肿瘤细胞移动和肿瘤新生血管的生成四个部分。Wnt/βcatenin信号转导通路的异常激活与神经胶质瘤侵袭密切相关。研究Wnt/βcatenin通路影响神经胶质瘤的侵袭机制，将为神经胶质瘤的治疗提供新的思路和靶点。

关键词: 神经胶质瘤, 肿瘤侵润, 微RNAs, Wnt/&beta, -链蛋白

Abstract: Invasion of glioma is a complex process with multiple steps and multiple factors, including the inhibition of tumor cell adhesion, the degradation of extracellular matrix, the promotion of tumor cells migration and angiogenesis. The abnormal activation of Wnt/βcatenin signaling pathway is closely related to the invasion of glioma. The study of Wnt/βcatenin pathway affecting invasion mechanism of glioma will provide new ideas and targets for the treatment of glioma.

Key words: Glioma, Neoplasm invasiveness, MicroRNAs, Wnt/β-catenin