国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (8): 706-710.doi: 10.3760/cma.j.issn.1673422X.2016.09.017

• 综述 • 上一篇    下一篇

长非编码RNA在消化系统肿瘤中的研究进展

潘磊,梁炜,付敏,钱晖,许文荣,蒋鹏程,张徐   

  1. 212013 镇江，江苏大学医学院分子生物学检验研究室（潘磊、梁炜、钱晖、许文荣、张徐）；江苏大学附属人民医院普外科（付敏、蒋鹏程）
  • 出版日期:2016-09-08 发布日期:2016-08-04
  • 通讯作者: 张徐，Email: xuzhang@ujs.edu.cn E-mail:xuzhang@ujs.edu.cn
  • 基金资助:

     国家自然科学基金（81201660）；江苏省自然科学基金（BK20141303）

Long noncoding RNA in digestive system tumors

Pan Lei, Liang Wei, Fu Min, Qian Hui, Xu Wenrong, Jiang Pengcheng, Zhang Xu   

  1. Department of Molecular Biology and Diagnostics, School of Medicine, Jiangsu University, Zhenjiang 212013, China
  • Online:2016-09-08 Published:2016-08-04
  • Contact: Zhang Xu E-mail:xuzhang@ujs.edu.cn
  • Supported by:

    National Natural Science Foundation of China (81201660)；Natural Science Foundation of Jiangsu Province of China (BK20141303)

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摘要： 长非编码RNA（lncRNA）是一类长度大于200个核苷酸的RNA分子，缺乏功能性开放阅读框，无编码蛋白能力。最近，越来越多的研究证据表明lncRNA促进了肿瘤的发生发展。lncRNA表达异常与消化系统肿瘤生长、转移及耐药等密切相关，可作为消化系统肿瘤诊断、治疗及预后判断的分子标志物。

关键词: 消化系统肿瘤, 肿瘤标记, 生物学, 长非编码RNA

Abstract: Long noncoding RNA (lncRNA) is a class of RNA molecules that longer than 200 nucleotides. lncRNA is lack of functional open reading frames and has no protein coding ability. Recently, accumulating evidences indicate that lncRNA plays active roles in tumor carcinogenesis and progression. The aberrant expression of lncRNA is significantly correlated with the growth, metastasis, and therapyresistance of digestive system tumors. Thus, lncRNA may be served as new targets for the diagnosis, treatment, and prognosis of patients with digestive system tumors.

Key words: Digestive system neoplasms, Tumor markers, biological, Long noncoding RNA