结肠癌转移相关基因1及其在肿瘤中的作用

doi:10.3760/cma.j.issn.1673-422X.2016.01.009

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (1): 32-35.doi: 10.3760/cma.j.issn.1673-422X.2016.01.009

结肠癌转移相关基因1及其在肿瘤中的作用

郭宏艳,何利珍,张云霏,张虹,金惠琴,安文文

730000 兰州，甘肃省第二人民医院病理科（郭宏艳、张云霏、张虹、金惠琴、安文文）；广州医科大学附属肿瘤医院病理科（何利珍）

收稿日期:2015-05-06 出版日期:2016-01-08 发布日期:2015-12-03
通讯作者: 郭宏艳 E-mail:pinghongrui@126.com
基金资助:
甘肃省卫生行业科研计划（GSWSKY-2015-17）

Metastasis-associated in colon cancer 1 and its role in cancer

Guo Hongyan, He Lizhen, Zhang Yunfei, Zhang Hong, Jin Huiqin, An Wenwen

Department of Pathology , Second People′s Hospital of Gansu Province, Lanzhou 730000, China

Received:2015-05-06 Online:2016-01-08 Published:2015-12-03
Contact: Guo Hongyan E-mail:pinghongrui@126.com
Supported by:
Health Industry Scientific Research Plan of Gansu Province of China (GSWSKY-2015-17)

摘要/Abstract

摘要： 结肠癌转移相关基因1（MACC1）编码的蛋白质在肝细胞生长因子/肝细胞生长因子受体（HGF/cMet）信号转导通路中转录激活cMet基因，上调cMet蛋白的表达，促进肿瘤细胞的侵袭和转移。MACC1蛋白高表达与人类多种肿瘤的发生和转移相关，如结肠癌、胃癌、肝癌、肺癌、卵巢癌等，且与肿瘤临床分期、有无远处转移密切相关，可作为肿瘤转移和预后判断的独立指标，为基因治疗提供新靶点。

关键词: 结肠肿瘤, 结肠癌转移相关基因1, 原癌基因蛋白质c-Met

Abstract: The protein product of metastasis-associated in colon cancer 1 (MACC1) gene induces the activation of hepatocyte growth factor/mesenchymalepithelial transition factor (HGF/c-Met) signaling pathway through transcriptionally activating cMet gene and upregulating its expression to further promote tumor invasion and metastasis. High level expression of MACC1 is associated with the occurrence and metastasis of a wide variety of human tumors, such as colon cancer, gastric cancer, liver cancer, lung cancer, ovarian cancer etc. In addition, the overexpression of MACC1 is also closely associated with clinical TNM stages and distant metastasis. Thus, MACC1 can serve as an independent indicator of tumor metastasis and prognosis, and become a new target for gene therapy.

Key words: Colonic neoplasms, Metastasis-associated in colon cancer 1, Proto-oncogene proteins c-Met

郭宏艳,何利珍,张云霏,张虹,金惠琴,安文文. 结肠癌转移相关基因1及其在肿瘤中的作用[J]. 国际肿瘤学杂志, 2016, 43(1): 32-35.

Guo Hongyan, He Lizhen, Zhang Yunfei, Zhang Hong, Jin Huiqin, An Wenwen. Metastasis-associated in colon cancer 1 and its role in cancer[J]. Journal of International Oncology, 2016, 43(1): 32-35.

参考文献

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结肠癌转移相关基因1及其在肿瘤中的作用

Metastasis-associated in colon cancer 1 and its role in cancer

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