国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 679-.doi: 10.3760/cma.j.issn.1673422X.2015.09.010

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CMTM家族在肿瘤中的表达及作用

周雅博, 蒋晔, 庞炳昕, 吴倩倩, 卢珈, 胡洁, 刘伟   

  1. 河北医科大学公共卫生学院
  • 出版日期:2015-09-08 发布日期:2015-08-12

The expression and role of CMTM family in tumor

ZHOU  Ya-Bo, JIANG  Ye, PANG  Bing-Xin, WU  Qian-Qian, LU  Jia, HU  Jie, LIU  Wei   

  1. School of Public Health, Hebei Medical University
  • Online:2015-09-08 Published:2015-08-12

摘要: CMTM家族基因在多种肿瘤中表达沉默或下调,其表达异常与肿瘤的发生发展和转移联系密切,是潜在的抑癌基因。表观遗传学是该家族基因表达异常的重要机制。这一研究发现为肿瘤的临床治疗提供了新的思路。

Abstract: CMTM family is silenced and downregulated in several kinds of tumors. Its aberrant expression has a strong association with the development, progression and metastasis of tumors. Thus, CMTM family is potential tumor suppressor genes. Epigenetics mechanism is the essential mechanism of the aberrant expression in this gene family. The discovery of this research gives a new direction to the clinical treatment of tumor.