国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 682-.doi: 10.3760/cma.j.issn.1673422X.2015.09.011

• 综述 • 上一篇    下一篇

野黄芩苷抗肿瘤作用机制

张少华, 路丹   

  1. 哈尔滨医科大学附属第二医院肿瘤内科
  • 出版日期:2015-09-08 发布日期:2015-08-12

Anticancer mechanism of scutellarin

ZHANG  Shao-Hua, LU  Dan   

  1. Department of Oncology Medicine, Second Affiliated Hospital of Harbin Medical University
  • Online:2015-09-08 Published:2015-08-12

摘要: 野黄芩苷(SC)是一种具有抑制自由基生成、抗炎、心肌保护和抗病毒等多种药理活性的中药提取物。近年研究表明SC对多种肿瘤的生长具有抑制作用,是一种潜在的抗肿瘤药物。其抗肿瘤机制主要有诱导细胞凋亡、阻遏细胞周期、增强黏附力及抗侵袭、逆转肿瘤多药耐药、抑制肿瘤血管新生等。

Abstract: Scutellarin (SC), a botanical extract, possesses a variety of suppressing free radical generation, antiinflammatory, cardioprotection and antivirus activity. Recently, many studies show that SC has inhibitory effects on the growth of many tumors and is a kind of potential antitumor drug. Its antitumor mechanisms mainly include inducing apoptosis, arresting cell cycle, enhancing the adhesion between cells, inhibiting tumor invasion, reversing multidrug resistance, anti-angiogenesis and so on.