白细胞介素28B rs12979860 T/C基因多态性与肝细胞癌易感性关系的Meta分析

doi:10.3760/cma.j.issn.1673422X.2015.05.006

摘要/Abstract

摘要： 目的探讨白细胞介素28B（IL28B）rs12979860 T/C基因多态性与肝细胞癌（HCC）易感性的关联。方法计算机检索PubMed、EMBase、中国知网数据库、中国生物医学文献数据库、维普数据库及万方数据库，检索时间截至2014年9月30日，收集有关IL28B rs12979860 T/C基因多态性与肝细胞癌易感性的病例对照研究。由2名研究者按照纳入和排除标准独立选择文献、提取资料，采用RevMan 5.2和Stata 12.0软件进行Meta分析。结果最终纳入6个病例对照研究，包括1 138例患者和955例对照。各遗传模型Meta分析结果显示，IL28B rs12979860 T/C多态性与肝细胞癌易感性的关联性有统计学意义，与基因型CC及CT+CC比较，基因型TT可增加人群罹患肝细胞癌的风险（TT∶CC：OR=2.26，95%CI为1.40～3.64，Z=3.33，P=0.000 9；TT∶CT+CC：OR=1.90，95%CI为1.23～2.93，Z=2.89，P=0.004）。种族来源的亚组分析结果显示，在白种人群中，IL28B rs12979860 T/C多态性与肝细胞癌易感性存在显著相关性（TT∶CC：OR=2.06，95%CI为1.22～3.47，Z=2.70，P= 0.007；TT∶CT+CC：OR=1.71，95%CI为1.07～2.72，Z=2.23，P= 0.03）。结论 IL28B rs12979860 T/C基因多态性与肝细胞癌易感性相关，基因型TT可增加罹患肝细胞癌的风险。

关键词: 肝肿瘤/多态现象, 遗传/Meta分析/白细胞介素-28B

Abstract: ObjectiveTo explore the correlation between polymorphism of interleukin28B (IL28B) rs12979860 T/C and susceptibility of hepatocellular carcinoma(HCC). MethodsAll eligible casecontrol studies published up to 20140930 were identified by searching PubMed, EMBase, CNKI, CBM, VIP and WanFang databases. Two reviews independently identified the literature according to inclusion and exclusion criteria. Metaanalysis was performed using Rev Man 5.2 and Stata 12.0 software. ResultsA total of 6 studies comprising 1 138 cases and 955 controls were finally included. Metaanalysis showed that IL28B rs12979860 T/C polymorphism was associated with the susceptibility of HCC. Compared with the genotype CC and CT+CC, genotype TT increased the risk of suffering from HCC(TT vs CC: OR=2.26, 95%CI: 1.403.64, Z=3.33, P= 0.000 9; TT vs CT+CC: OR=1.90, 95%CI: 1.232.93, Z=2.89, P= 0.004). In stratification analysis by ethnicity, we observed that the polymorphism of IL28B rs12979860 T/C was associated with the susceptibility of HCC among Caucasian populations (TT vs CC: OR=2.06, 95%CI: 1.223.47, Z=2.70, P=0.007; TT vs CT+CC: OR=1.71, 95%CI: 1.072.72, Z=2.23, P= 0.03). Conclusion The polymorphism of IL28B rs12979860 T/C is associated with the susceptibility of HCC, genotype TT may increase the susceptibility to HCC.

刘佳, 朱琴梅, 胡弘毅, 王甦. 白细胞介素28B rs12979860 T/C基因多态性与肝细胞癌易感性关系的Meta分析[J]. 国际肿瘤学杂志, 2015, 42(5): 342-346.

LIU Jia, ZHU Qin-Mei, HU Hong-Yi, WANG Su. Association between polymorphism of interleukin28B rs12979860 T/C and susceptibility of hepatocellular carcinoma: a Metaanalysis[J]. Journal of International Oncology, 2015, 42(5): 342-346.

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