国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (3): 221-223.doi: 10.3760/cma.j.issn.1673422X.2015.03.016

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胃癌患者营养不良相关因子研究进展

李蓉,杨小芸,沈丽达   

  1. 650118 昆明医科大学第三附属医院 云南省肿瘤医院内一科
  • 出版日期:2015-03-08 发布日期:2015-01-29
  • 通讯作者: 沈丽达，Email:shenlida2560@qq.com E-mail:shenlida2560@qq.com
  • 基金资助:

    云南省卫生科技计划项目（2012WS0036）

Malnutrition related factors in patients with gastric cancer

Li Rong， Yang Xiaoyun， Shen Lida   

  1. The 1st Department of Medical Oncology of The Third Affiliated Hospital of Kunming Medical University， Tumor Hospital of Yunnan Province， Kunming 650118， China
  • Online:2015-03-08 Published:2015-01-29
  • Contact: Shen Lida E-mail:shenlida2560@qq.com

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被引次数

1

摘要： 胃癌患者的预后与营养不良密切相关，导致胃癌患者营养不良的机制目前并不十分明确，除了厌食、进食困难等，胃癌患者营养不良可能与宿主肿瘤相互作用产生具有代谢活性的因子如肿瘤坏死因子α、白细胞介素1、白细胞介素6、干扰素、瘦素、核因子κB等。相关因子之间关系复杂，相互调控，构成一个精密的调控网络。因此，进一步探索胃癌患者营养不良与相关因子之间的关系，可能为改善患者营养状况及预后提供一定的研究基础。

关键词: 胃肿瘤, 细胞因子类, 营养状况

Abstract: Malnutrition is one of the most important factors for the prognosis of patients with gastric cancer, but the mechanism of malnutrition is unclear at present. These patients are at risk of nutritional depletion from anorexia, dysphagia, and may be associated with the presence of two or more of the following cytokines with metabolic activity such as TNFα, IL1, IL6, interferon, leptin, nuclear factorκB and so on, which are secreted by  the hosttumor interaction. The cytokines constitute a sophisticated regulatory network. Therefore, the study of the relationship between malnutrition and related factors in patients with gastric cancer may improve the nutritional status and prognosis of these patients.

Key words: Stomach neoplasms, Cytokines, Nutritional status