国际肿瘤学杂志

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (3): 196-199.doi: 10.3760/cma.j.issn.1673422X.2015.03.009

• 综述 • 上一篇    下一篇

表观遗传学修饰与非小细胞肺癌

 赵晨卉, 束永前   

  1. 210029 南京医科大学第一附属医院肿瘤科
  • 出版日期:2015-03-08 发布日期:2015-01-29
  • 通讯作者: 束永前，Email: shuyqtg@126.com E-mail:shuyqtg@126.com
  • 基金资助:

    国家自然科学基金（81272532）

Epigenetic modifications and nonsmall cell lung cancer

 ZHAO  Chen-Hui, SHU  Yong-Qian   

  1. Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2015-03-08 Published:2015-01-29
  • Contact: Shu Yongqian E-mail:shuyqtg@126.com

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被引次数

2

摘要： 【摘要】在非小细胞肺癌（NSCLC）中，基因异常甲基化是其主要特征。原癌基因的低甲基化有致癌潜能，而抑癌基因的高甲基化也可诱发肿瘤。此外，组蛋白乙酰化和去乙酰化修饰的平衡与肿瘤的形成密切相关。组蛋白乙酰化酶能直接乙酰化增生相关基因，导致细胞的增殖转化；而组蛋白去乙酰化酶也能改变某些基因组蛋白的乙酰化水平，影响NSCLC的发生与发展。由此可见，这些表观遗传学的异常在NSCLC的形成和发展中起到了极为重要的作用。

关键词: 后成说, 遗传, DNA甲基化, 组蛋白类, 乙酰化作用, 癌, 非小细胞肺

Abstract: In nonsmall cell lung cancer (NSCLC), a major characteristic is the abnormal methylation of some certain genes. The hypomethylation of protooncogene has the potential to promote carcinogenesis and the formation of neoplasm may also be induced by the hypermethylation of tumor suppressor genes. Meanwhile, the balance between histone acetylation and deacetylation is closely connected to the tumorigenesis. While the histone acetyltransferases can directly acetylate genes related to proliferation, causing cell growth and transformation, histone deacetylase will also alter the level of acetylation of certain proteins, and eventually affect NSCLC. Hence, these abnormal epigenetic modifications play a fundamental role in the formation and development of NSCLC.

Key words: Epigenesis, genetic, DNA methylation, Histones, Acetylation, Carcinoma, nonsmallcell lung