国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 463-466.doi: 10.3760/cma.j.issn.1673422X.2014.06.019

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微小RNA与弥漫大B细胞淋巴瘤

王馨瑗,杨锡贵,姜超   

  1. 250117济南，济南大学 山东省医学科学院医学与生命科学学院（王馨瑗）;山东省肿瘤医院内科（王馨瑗、杨锡贵、姜超）
  • 出版日期:2014-06-08 发布日期:2014-05-08
  • 通讯作者: 杨锡贵，Email:zlysxgy@126.com E-mail:zlysxgy@126.com

MicroRNA and diffuse large Bcell lymphoma

Wang Xinyuan*, Yang Xigui, Jiang Chao   

  1. *School of Medical and Life Sciences, Shandong Academy of Medical Sciences, Jinan University; Department of Medical Oncology, Shandong Cancer Hospital, Jinan 250117, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Yang Xigui E-mail:zlysxgy@126.com

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摘要： DNA甲基转移酶1（DNMT1）作为DNA甲基转移酶（DNMT）家族的主要成员，对维持和调节肿瘤细胞全基因组和局部区域甲基化起着核心作用。DNMT1在妇科恶性肿瘤中高表达，引起基因DNA的甲基化异常，特别是抑癌基因的高甲基化，继而造成相关基因表达沉默，导致细胞的恶性生长。

关键词: 微RNAs, 淋巴瘤, 大B细胞, 弥漫性

Abstract: MicroRNA (miRNA) is a kind of naturally occurring short noncoding small molecular RNA, which regulates gene expression at the posttranscriptional level through its sequence complementation with target mRNAs. Researches have shown that different malignant tumors, including diffuse large B cell lymphoma, have specific miRNA expression profiles. Therefore, miRNAs expression level of specimens of body fluids and tissues is expected to be the new indicator for assessing diffuse large B cell lymphoma.

Key words: MicroRNAs, Lymphoma, large Bcell, diffuse