国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (6): 458-460.doi: 10.3760/cma.j.issn.1673422X.2014.06.017

• 综述 • 上一篇    下一篇

DNA甲基转移酶1与妇科恶性肿瘤

王玲, 金平   

  1. 710000 西安，西北妇女儿童医院（王玲）；南方医科大学附属深圳市妇幼保健院（金平）
  • 出版日期:2014-06-08 发布日期:2014-05-08
  • 通讯作者: 金平 E-mail:pingjin66@sina.com

DNA methyctransferase 1 and gynecological malignancies

 WANG  Ling, JIN  Ping   

  1. *Department of Obstetrics and Gynecology of the Northwest Women′s and Children′s Hospital, Xi′an 710000, China
  • Online:2014-06-08 Published:2014-05-08
  • Contact: Jin Ping E-mail:pingjin66@sina.com

摘要： DNA甲基转移酶1（DNMT1）作为DNA甲基转移酶（DNMT）家族的主要成员，对维持和调节肿瘤细胞全基因组和局部区域甲基化起着核心作用。DNMT1在妇科恶性肿瘤中高表达，引起基因DNA的甲基化异常，特别是抑癌基因的高甲基化，继而造成相关基因表达沉默，导致细胞的恶性生长。

关键词: 位点特异性DNA甲基转移酶（胞嘧啶特异性）, 生殖器肿瘤, 女（雌性）

Abstract: DNMT1，the main member of the DNA methyltransferase (DNMT) family,  plays a core role  in maintaining and regulating tumor cell genomewide and the local area methylation. DNMT1 is highly expressed in gynecological malignancies, which leads to abnormal DNA methylation of genes, especially high methylation of tumor suppressor genes, gene expression silencing, and malignant cell growth.

Key words: Sitespecific DNA methyltransferase (cytosinespecific), Genital neoplasms,female