国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (4): 309-314.doi: 10.3760/cma.j.issn.1673422X.2014.04.021

• 论著 • 上一篇    下一篇

GSTP1 Ile105Val(A/G)多态性与进展期胃癌铂类药物化疗敏感性的Meta分析

邓成辉,关泉林,姜雷,李小奇,甘亮亮,魏孔孔   

  1. 730000 兰州大学第一临床医学院（邓成辉、李小奇、甘亮亮、魏孔孔）；兰州大学第一医院肿瘤外科（关泉林、姜雷）
  • 出版日期:2014-04-08 发布日期:2014-03-17
  • 通讯作者: 关泉林，Email: guanquanlin2013@163.com E-mail:guanquanlin2013@163.com
  • 基金资助:

    中央高校基本科研业务费专项资金（lzujbky2013160）

Association between Ile105Val polymorphism of GSTP1 and sensitivity to platinumbased chemotherapy in advanced gastric cancer: a Metaanalysis

DENG  Cheng-Hui, GUAN  Quan-Lin, JIANG  Lei, LI  Xiao-Qi, GAN  Liang-Liang, WEI  Kong-Kong   

  1. First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: Guan Quanlin E-mail:guanquanlin2013@163.com

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摘要： 目的定量评价进展期胃癌患者中谷胱甘肽S转移酶pi（GSTP1）基因105氨基酸位点Ile/Val多态性与铂类药物化疗敏感性的关系。方法检索中国期刊全文数据库（CNKI）、中文科技期刊全文数据库（VIP）、中国生物医学文献数据库（CBM）、万方数据库、PubMed、EMBASE、Cochrane Library，收集国内外公开发表的关于GSTP1 Ile105Val基因多态性与胃癌铂类药物化疗敏感性关系的文献。临床有效（完全缓解+部分缓解）作为评价化疗敏感性的指标。运用RevMan 5.2进行Meta分析，计算合并比值比（OR）及95%可信区间（CI），运用Stata 12.0识别是否存在发表偏倚。结果本研究纳入6项研究共计病例724例，Meta分析结果显示，各基因型间（GG+GA vs AA：OR=2.38，95%CI为1.29～4.38；GG vs GA+AA：OR=3.66，95%CI为1.18～11.39；GG vs AA：OR=4.42，95%CI为1.28～15.26）以及亚洲人群亚组（GG+GA vs AA：OR=2.93，95%CI为1.33～6.48）中GSTP1 Ile105Val多态性与化疗敏感性的差异有统计学意义。结论GSTP1 Ile105Val(A/G)基因多态性可能与进展期胃癌铂类化疗药物敏感性相关。

关键词: 胃肿瘤, 药物疗法, 多态性, 单核苷酸, Meta分析, 谷胱甘肽S转移酶pi

Abstract: ObjectiveTo quantitatively evaluate the association between Ile105Val polymorphism of glutathione Stransferase pi (GSTP1) and sensitivity to platinumbased chemotherapy in advanced gastric cancer. MethodsThe relevant published literatures about Ile105Val polymorphism of GSTP1 and sensitivity to platinumbased chemotherapy in gastric cancer were retrieved from China National Knowledge Internet (CNKI), VIP, Chinese Biomedical Literature Data (CBM), WanFang databases, PubMed, EMBASE and Cochrane Library. Clinical response (complete response and partial response) was employed to estimate chemosensitivity. Metaanalysis was conducted by the RevMan 5.2 software, odds ratio (OR) with 95% confidence interval (CI) were calculated. Publication bias was identified using Stata 12.0 software. ResultsA total of 724 cases from 6 casecontrol trials were included. The results of Metaanalysis showed the different statistical significance was found between GSTP1 Ile105Val polymorphism and clinical response in the follow genotypes ［GG+GA vs AA: OR=2.38, 95%CI (1.29～4.38); GG vs GA+AA: OR=3.66, 95%CI (1.18～11.39); GG vs AA: OR=4.42, 95%CI (1.28～15.26)］ and Asian population subgroups ［GG+GA vs AA: OR=2.93, 95%CI (1.33～6.48)］. ConclusionPolymorphism of GSTP1 Ile105Val(A/G) may be associated with platinumbased chemosensitivity in advanced gastric cancer.

Key words: Stomach neoplasms, Drug therapy, Polymorphism, single nucleotide, Metaanalysis, Glutathione Stransferase pi