Toll样受体信号通路在宫颈高危HPV感染致癌过程中的相关功能

doi:10.3760/cma.j.issn.1673-422X.2014.11.013

摘要/Abstract

摘要： Toll样受体(TLR)是最特征性的病原模式识别受体，在宫颈人乳头瘤病毒(HPV)感染的过程中，TLR信号通路影响了HPV感染的转归，在宫颈高危HPV感染至宫颈癌变的进程中起到促进或抑制肿瘤的免疫调节作用。TLR的基因多态性与宫颈癌的发生也密切相关。

关键词: 宫颈肿瘤, 人乳头瘤状病毒感染, Toll样受体

Abstract: Toll like receptors (TLRs) are the most characteristic of pathogen recognition receptors. TLR signal pathway affects the outcome of cervical HPV infection, and plays double roles of promoting or inhibiting tumor in immune regulation for the process from highrisk HPV infection to cervical cancer. The polymorphism of TLR gene is closely related to the occurrence of cervical cancer.

Key words: Uterine cervical neoplasms, Papillomavirus infections, Tolllike receptors

徐小仙, 楼寒梅. Toll样受体信号通路在宫颈高危HPV感染致癌过程中的相关功能[J]. 国际肿瘤学杂志, 2014, 41(11): 840-843.

XU Xiao-Xian, LOU Han-Mei. Function of Toll like receptor signaling pathway in the carcinogenesis process related to high risk HPV infection of cervical[J]. Journal of International Oncology, 2014, 41(11): 840-843.

参考文献

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