国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (5): 359-362.

• 综述 • 上一篇    下一篇

胃癌中微小RNA相关研究进展

韩静, 凌志强   

  1. 310022杭州，浙江省肿瘤医院 浙江省肿瘤研究所遗传室（韩静、凌志强）；325035温州医学院检验医学院 生命科学学院（韩静）
  • 出版日期:2013-05-08 发布日期:2013-05-15
  • 通讯作者: 凌志强 E-mail:lingzq@hotmail.com

Progression of microRNA in gastric cancer

HAN  Jing, LING  Zhi-Qiang   

  1. Department of Genetics, Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China; *School of Laboratory Medicine and Life Science, Wenzhou Medical College, Wenzhou 325035, China
  • Online:2013-05-08 Published:2013-05-15
  • Contact: LING Zhi-qiang E-mail:lingzq@hotmail.com

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摘要： 近期大量研究发现微小RNA在胃癌的发展、诊断、治疗与预防等方面都起着关键性作用。已有报道证实miR-451可以作为一种有用的生物标志物用于胃癌的筛查，miR-203、miR-21可能成为胃癌诊断的标志物。微小RNA既可以发挥癌基因作用，也可以发挥抑癌基因作用，如miR-141通过对正成纤维细胞生长因子受体2基因表达的抑制来发挥抑癌基因的作用。

关键词: 胃肿瘤, 微RNAs

Abstract: Recently, many studies find that microRNA plays a key role in the development, diagnosis, treatment and prevention of gastric cancer. It is confirmed that miR-451 can be used as a useful biomarker for the screening of gastric cancer. Studies also confirmed that miR-203 and miR-21 may become diagnostic markers of gastric cancer. MicroRNA can play the role of oncogenes, and also can play the role of tumor suppressor gene, such as miR-141 plays the role of tumor suppressor gene through inhibition of the positive fibroblast growth factor receptor 2 gene expression.

Key words: Gastric neoplasms, MicroRNAs