国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (8): 669-671.

• 综述 • 上一篇    下一篇

白细胞介素-32研究进展

李松林,尹元琴   

  1. 110001沈阳,中国医科大学附属第一医院肿瘤研究所二室
  • 出版日期:2012-09-22 发布日期:2012-09-24
  • 通讯作者: 尹元琴,E-mail:yuandouwang@yahoo.com.cn E-mail:yuandouwang@yahoo.com.cn

Research progress of interleukin-32

 LI  Song-Lin, YIN  Yuan-Qin   

  1. Second Department,Tumor Institute, the First Affiliated Hospital, China Medical University, Shenyang  110001, China
  • Online:2012-09-22 Published:2012-09-24
  • Contact: YIN Yuan-qin,E-mail:yuandouwang@yahoo.com.cn E-mail:yuandouwang@yahoo.com.cn

摘要: 白细胞介素-32(IL-32) 是新近发现的一种细胞因子,体内外研究证明,它能通过抑制核转录因子-κB (NF-κB)、信号传导及转录激活因子3等通路抑制结肠癌及黑素瘤细胞的生长,促进其凋亡。此外,在慢性髓细胞性白血病、肉瘤、前列腺癌中能够通过不同的途径抑制肿瘤生长。

关键词: 白细胞介素-32, 转录因子, 死亡受体

Abstract: Interleukin-32 is a newly descovered cytokine. In vivo and in vitro studies show that it inhibits the proliferation and induces apoptosis of colon cancer and melanoma by inhibiting NF-κB and signaling and transcription activated factor 3 pathways. In addition, IL-32 suppresses tumor growth in different ways in chronic myelogenous leukemia, sarcoma and prostate cancer.

Key words: Interleukin-32, Transcription factors, Death receptor