国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (4): 301-304.

• 综述 • 上一篇    下一篇

异基因干细胞移植治疗多发性骨髓瘤

周世秋, 娄世锋, 罗云   

  1. 400010 重庆医科大学附属第二医院血液内科

  • 出版日期:2012-04-08 发布日期:2012-03-28

Allogeneic stem cell transplantation in multiple myeloma

ZHOU  Shi-Qiu, LOU  Shi-Feng, LUO  Yun   

  1. Department of Hemotology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
  • Online:2012-04-08 Published:2012-03-28

PDF

1749

被引次数

34

摘要： 异基因干细胞移植是惟一可能治愈多发性骨髓瘤（MM）的临床方法。较高的移植相关死亡率（TRM）限制了清髓性异基因干细胞移植在临床的广泛应用；非清髓性异基因干细胞移植降低了TRM，但疾病复发和进展的风险却增加；自体-非清髓性异基因干细胞串联移植，在降低TRM的同时，可有效减少疾病的复发和进展。目前临床上亦存在很多可能提高MM移植疗效的新方法。

关键词: 多发性骨髓瘤, 干细胞移植, 治疗学

Abstract: Allogeneic stem cell transplantation is the only treatment which may cure multiple myeloma (MM). The high transplantation related mortality (TRM) limits the wide clinical application of myeloablative allogeneic stem cell transplantation. Non-myeloablative allogeneic stem cell transplantation can reduce the TRM, but the risk of relapse and progress of the disease may get increased. Auto- nonmyeloablative allogeneic stem cell tandem transplantation can reduce both the TRM and the relapse and progress of the disease. At present, there exist many new methods which may improve the effect of allogeneic stem cell transplantation for MM in clinical.

Key words: Multiple myeloma, Stem cell transplantation, Therapeutics