国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 808-811.

• 综述 • 上一篇    下一篇

循环内皮细胞在临床肿瘤学的研究进展

熊鸣, 乔媛媛   

  1. 100048 北京，海军总医院基础医学研究中心
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 基金资助:

    海军总医院创新培育基金资助项目（CX201106）

Circulating endothelial cells in clinical oncology

XIONG  Ming, QIAO  Yuan-Yuan   

  1. Center of Basic Medical Science, Navy General Hospital of Chinese PLA , Beijing 100048,China
  • Online:2012-11-08 Published:2012-11-16

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摘要： 循环内皮细胞（CEC）是从血管壁脱落并进入血液循环中的成熟的内皮细胞，CEC数量增加反映显著的血管损伤和功能障碍。在多种以血管损伤为标志的疾病，包括不同类型的肿瘤中，CEC数量均呈不同程度增加。临床数据显示，CEC计数有助于评价肿瘤预后和治疗反应，是监测临床肿瘤进展潜有力的工具。

关键词: 新生血管化, 病理性, 肿瘤标记, 生物学, 循环内皮细胞

Abstract: Circulating endothelial cells（CECs）are mature endothelial cells, which have been shed from the vascular cell lining and enter into blood circulation. Rare in healthy individuals, increased CECs in peripheral blood reflects significant vascular damage and dysfunction. Increased CECs have been documented in many human diseasescharacterized as vascular damage, including different types of tumors. Clinical data suggest that CECs count is a promising tool for monitoring disease activity with potential to assess tumor prognosis and response to treatment.

Key words: color: black, font-size: 10.5pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-bidi-font-size: 12.0pt" lang="EN-US">Neovascularization, pathologic, color: black, font-size: 10.5pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-bidi-font-size: 12.0pt" lang="EN-US">Tumor markers, biological, color: black, font-size: 10.5pt, mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-bidi-font-size: 12.0pt" lang="EN-US">Circulating endothelial cells