国际肿瘤学杂志

国际肿瘤学杂志 ›› 2012, Vol. 39 ›› Issue (11): 803-805.

• 综述 •    下一篇

长链非编码RNA在恶性肿瘤中生物学作用的研究进展

刘畅, 焦旸   

  1. 215123 苏州大学医学部放射医学与防护学院 江苏省放射医学与防护重点实验室 苏州市肿瘤放射生物学重点实验室
  • 出版日期:2012-11-08 发布日期:2012-11-16
  • 基金资助:

    教育部博士点新教师基金项目（K51260110）,江苏高校优势学科建设工程资助项目（PAPD）

Biological function of long non-coding RNAs in human malignant neoplasms

LIU  Chang, JIAO  Yang   

  1. Key laboratory of Radiation Oncology of Suzhou, Jiangsu Province Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China
  • Online:2012-11-08 Published:2012-11-16

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摘要： 长链非编码RNA(lncRNA)是一类没有或很少具有开放阅读框架的、不能或极少编码蛋白质的RNA。近年来研究发现lncRNA在恶性肿瘤中有显著的组织特异性，并且在恶性肿瘤的临床诊断及预后判断中可能发挥重要作用。

关键词: color: black, font-size: 12pt, mso-hansi-font-family: 'Times New Roman', mso-bidi-font-family: 'Times New Roman', mso-font-kerning: 1.0pt, mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA">肿瘤, 肿瘤转移, 诊断, 预后, 长链非编码RNA

Abstract: Long non-coding RNAs(LncRNAs) refer to such a kind of RNAs which possess none or very few open reading frames, thus could only encode none or little protein. Recent studies suggest that LncRNAs tissue- specially expressed in several human cancers，and might play a key role in the diagnosis and prognostic of these malignant neoplasms.

Key words: Neoplasms, Neoplasms metastasis, Diagnosis, Prognostic, Long non-coding RNA