Abstract: MicroRNAs (miRNAs) are a class of small, non-coding, single-stand RNA molecules which are composed of 21～25 ribonucleotides. They regulate gene expression at post-transcription and participate in many important biological processes including cell growth, apoptosis, viral infection and cancer development. At present, the studies on miRNAs in cervical lesion include miRNAs expression characteristic of cervical cancer and precancerous lesion, the association with HPV infection and prognosis of cervical lesion, cervical cancer development，diagnosis and therapy.