国际肿瘤学杂志

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (10): 750-753.

• 综述 • 上一篇    下一篇

获取肿瘤抗原的研究方法

方晓瑞, 郝萍   

  1. 650032 昆明医学院第一附属医院临床试验中心
  • 出版日期:2011-10-08 发布日期:2011-09-27
  • 通讯作者: 郝萍，E-mail:hping92@hotmail.com E-mail:hping92@hotmail.com
  • 基金资助:

    国家自然科学基金资助项目（30260103）

Advances in the methods of acquiring tumor antigens

FANG  Xiao-Rui, HAO  Ping   

  1. Clinical Trials Center, First Affiliated Hospital, Kunming Medical College, Kunming 650032, China
  • Online:2011-10-08 Published:2011-09-27

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摘要： 如何获取新的肿瘤抗原是目前肿瘤研究的热点。根据抗原表位和其配体结合的性质，通过某些特定的实验分析技术从抗原刺激的T细胞和特异性单克隆抗体层面分离鉴定可以得到未知抗原及其表位，甚至是它们的氨基酸序列，因此肿瘤免疫的分子机制将会越来越清楚。

Abstract: How to acquire new tumor antigens is a hotspot in cancer research currently. According to the nature of antigen epitope binding its ligand, we can identify and get unknown antigen epitope even its amino acid sequence through some analytical techniques and experiments, from T lymphocytes and monoclonal antibody levels. So the molecular mechanisms of tumor immunity will be more distinct.