国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (10): 747-750.

• 综述 • 上一篇    下一篇

结肠癌转移相关基因1与肿瘤转移

张敏, 任德莲   

  1. 646000 泸州医学院免疫学教研室
  • 出版日期:2011-10-08 发布日期:2011-09-27

MACC1 and tumor metastasis

ZHANG  Min, REN  De-Lian   

  1. Department of Immunology, Luzhou Medical College,Luzhou 646000,China
  • Online:2011-10-08 Published:2011-09-27
  • Contact: 任德莲,E-mail:rendelian5405@163.com E-mail:rendelian5405@163.com

摘要: 新近研究发现,结肠癌转移相关基因1(MACC1)在人类多种肿瘤中存在异常高表达,作为HGF-MET信号通路的关键调控者,可以明显上调MET蛋白的表达,促进肿瘤细胞的运动、侵袭和转移。进一步的研究将有助于阐明肿瘤转移的机制,同时也为肿瘤转移靶向治疗提供了新思路。

Abstract: Recent findings indicate that metastasis-associated gene in colon cancer 1  (MACC1) has an abnormal high expression in most malignant tumors. As a key regulator of HGF-MET signal pathway, MACC1 could obviously up-regulate the expression of MET and promote cancer cell’s movement, invasion and metastasis. Further studies will shed light on elucidating the mechanisms of metastasis and may provide a new method for targeted therapy.