高迁移率族蛋白A1在肿瘤中的作用及其机制

国际肿瘤学杂志 ›› 2011, Vol. 38 ›› Issue (10): 744-747.

高迁移率族蛋白A1在肿瘤中的作用及其机制

周锐, 王圣应

蚌埠医学院第一附属医院肿瘤外科

出版日期:2011-10-08 发布日期:2011-09-27

Function and mechanism of the high mobility group protein A1 in tumor

ZHOU Rui, WANG Sheng-Ying

Department of Surgical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China

Online:2011-10-08 Published:2011-09-27

摘要/Abstract

摘要： 高迁移率族蛋白A1（HMGA1）是非组蛋白染色质蛋白超家族的成员，广泛存在于真核生物细胞核中，主要参与对基因表达转录的调控。研究表明几乎所有的人类恶性肿瘤中都有HMGA1异常表达，其在癌症的发生发展中可能有重要的作用，但具体致癌机制尚未完全清楚。构建的HMGA1转染系统在以后的肿瘤研究中将有潜在的应用价值, 也为肿瘤的治疗提供了新的思路。

Abstract: High mobility group protein A1 (HMGA1) are members of a superfamily of non-histone chromatin proteins, which exist widely in eukaryotic nuclei and are mainly involved in transcriptional regulation of gene expression. Recent researches show that almost all human malignant tumors have abnormal expression of HMGA1, which may have an important role in the development of cancer, but the exact mechanism is not clear yet. In cancer research, transfection system which constructed on the basis of HMGA1 will have potential value, and also could shed some light on the treatment of cancer.

周锐, 王圣应. 高迁移率族蛋白A1在肿瘤中的作用及其机制[J]. 国际肿瘤学杂志, 2011, 38(10): 744-747.

ZHOU Rui, WANG Sheng-Ying. Function and mechanism of the high mobility group protein A1 in tumor[J]. Journal of International Oncology, 2011, 38(10): 744-747.