乙醇致食管癌发病机制

doi:10.3760/cma.j.issn.1673422X.2018.02.014

国际肿瘤学杂志 ›› 2018, Vol. 45 ›› Issue (2): 119-121.doi: 10.3760/cma.j.issn.1673422X.2018.02.014

乙醇致食管癌发病机制

林涛, 马冬春, 王华, 解明然, 张天赐

230001 合肥，安徽医科大学附属省立医院胸外科（林涛、马冬春、解明然、张天赐）；安徽医科大学第一附属医院肿瘤科（王华）·

出版日期:2018-02-08 发布日期:2018-02-28
通讯作者: 马冬春，Email: madongchun126@126.com E-mail:madongchun126@126.com
基金资助:
安徽省卫生计生委科研计划（15tb006）

Pathogenesis of ethanolinduced esophageal cancer

Lin Tao, Ma Dongchun, Wang Hua, Xie Mingran, Zhang Tianci

Department of Toracic Surgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China

Online:2018-02-08 Published:2018-02-28
Contact: Ma Dongchun E-mail:madongchun126@126.com
Supported by:
Scientific Research Project of Health and Family Planning Commission of Anhui Province of China（15tb006）

摘要/Abstract

摘要： 乙醇是食管癌发病的主要危险因素之一。乙醇引起食管癌的主要发病机制包括乙醇代谢产物乙醛的直接致癌作用、乙醇代谢相关酶类的基因多态性、活性氧的致癌作用、乙醇引起的营养物质代谢紊乱、乙醇与烟草的协同作用。

关键词: 食管肿瘤, 乙醇

Abstract: Ethanol is one of the major risk factors for esophageal cancer. The main mechanisms of ethanol induced esophageal cancer include the direct carcinogenesis of acetaldehyde, the genetic polymorphism of enzymes related to alcohol metabolism, the carcinogenic effect of reactive oxygen species, the disorder of nutrient metabolism induced by ethanol, and the synergistic effect of ethanol and tobacco.　　

Key words: Esophageal neoplasms, Ethanol

林涛, 马冬春, 王华, 解明然, 张天赐. 乙醇致食管癌发病机制[J]. 国际肿瘤学杂志, 2018, 45(2): 119-121.

LIN Tao, MA Dong-Chun, WANG Hua, JIE Ming-Ran, ZHANG Tian-Ci. Pathogenesis of ethanolinduced esophageal cancer[J]. Journal of International Oncology, 2018, 45(2): 119-121.

参考文献

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乙醇致食管癌发病机制

Pathogenesis of ethanolinduced esophageal cancer

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