国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 710-.doi: 10.3760/cma.j.issn.1673422X.2015.09.019

• 综述 • 上一篇    下一篇

结直肠癌个体化治疗中的预测因子

张一帆, 殷海涛   

  1. 徐州市中心医院放疗科
  • 出版日期:2015-09-08 发布日期:2015-08-12

Biomarkers of colorectal cancer in individual therapy

ZHANG  Yi-Fan, YIN  Hai-Tao   

  1. Department of Radiation Oncology, Xuzhou Central Hospital
  • Online:2015-09-08 Published:2015-08-12

摘要: 在结直肠癌的分子生物学领域,存在一些可以预测疗效和不良反应的标志物,包括乳清酸磷酸核糖基转移酶、P53、胸苷酸合成酶、谷胱甘肽巯基转移酶、亚甲基四氢叶酸还原酶、二氢嘧啶脱氢酶、尿苷二磷酸葡萄糖苷酸转移酶等,它们可以为挑选预计有效的患者或是筛选出预计不能耐受不良反应的患者提供帮助,有助于完善结直肠癌的个体化治疗。

Abstract: In the field of colorectal cancer molecular biology, there are a number of biomarkers of prognosis and curative effect, including orotate phosphoribosyltransferase, P53, thymidylate synthase, glutathione Stransferase, methylenetetrahydrofolate reductase, dihydropyfimidine dehydrogenase, uridinediphosphoglucuronosyl transferase, which can select the effective patients or the patients who can′t bear the side effects and contribute to the individualized treatment of colorectal cancer.