叉头盒蛋白A1在乳腺癌的作用

doi:10.3760/cma.j.issn.1673422X.2015.09.017

国际肿瘤学杂志 ›› 2015, Vol. 42 ›› Issue (8): 702-.doi: 10.3760/cma.j.issn.1673422X.2015.09.017

叉头盒蛋白A1在乳腺癌的作用

罗香蓉, 魏晓龙, 陈伟玲, 张国君

汕头大学医学院附属肿瘤医院乳腺中心汕头大学医学院长江学者实验室广东省乳腺癌诊治研究重点实验室

出版日期:2015-09-08 发布日期:2015-08-12

Research advances on the significance of FOXA1 in breast cancer

LUO Xiang-Rong, WEI Xiao-Long, CHEN Wei-Ling, ZHANG Guo-Jun

The Breast Center, Cancer Hospital of Shantou University Medical College/ChangJiang Scholor′s Lab, Shantou University Medical College，Guangdong Provincial Key Laboratory for Breast Cancer Diagnosis&Treatment

Online:2015-09-08 Published:2015-08-12

摘要/Abstract

摘要： 叉头盒蛋白A1（FOXA1）基因在人体许多组织如乳腺、肝、胰腺、膀胱、前列腺、结肠、卵巢、肺和食管中表达，其表达与这些器官的发育及这些器官的肿瘤发生密切相关。目前研究发现其在调节细胞增殖、分化、发育及肿瘤形成、上皮间质转化（EMT）等过程中起重要作用，其表达与与ER、PR呈正相关，是乳腺癌良好预后的重要预测因子之一。

Abstract: Forkhead box A1 (FOXA1) is expressed in various organs, including breast, liver, pancreas, bladder, prostate, colon, ovary, lung and esophagus. The FOXA1 expression is associated with the growth and carcinogenesis of these organs. It is recently demonstrated FOXA1 plays a significant role in different biological processes including cell proliferation,differentiation,devolopment,carcinogenesis and the process of epithelialmesenchymal transition (EMT)etc. Its expression is positively correlated with ER and PR expression, and it is demonstrate to be one of the most important favorate prognostic factors of breast cancer.

罗香蓉, 魏晓龙, 陈伟玲, 张国君. 叉头盒蛋白A1在乳腺癌的作用[J]. 国际肿瘤学杂志, 2015, 42(8): 702-.

LUO Xiang-Rong, WEI Xiao-Long, CHEN Wei-Ling, ZHANG Guo-Jun. Research advances on the significance of FOXA1 in breast cancer[J]. Journal of International Oncology, 2015, 42(8): 702-.

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叉头盒蛋白A1在乳腺癌的作用

Research advances on the significance of FOXA1 in breast cancer

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