国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (4): 258-260.doi: 10.3760/cma.j.issn.1673422X.2014.04.006

• 综述 • 上一篇    下一篇

碳纳米管结合药物在肿瘤靶向治疗中的应用

蒋文彬, 温诗辉, 赵庆华   

  1. 200080 上海交通大学附属第一人民医院骨科（蒋文彬、赵庆华）；东华大学化学化工与生物工程学院（温诗辉）
  • 出版日期:2014-04-08 发布日期:2014-03-17
  • 通讯作者: 赵庆华，Email: sawboneszhao@163.com E-mail:sawboneszhao@163.com

Application of functionalized carbon nanotube in tumor targeted therapy

JIANG  Wen-Bin, WEN  Shi-Hui, ZHAO  Qing-Hua   

  1. Department of Osteology, Affiliated First People′s Hospital of Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: Zhao Qinghua E-mail:sawboneszhao@163.com
  • Supported by:

    上海交通大学医工（理）交叉研究基金（YG2011MS28）

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被引次数

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摘要： 将药物定点运输至相关组织以提高药物利用率、降低细胞毒性的手段称为靶向治疗。以碳纳米管为载体的结合化疗药物与单纯使用药物相比，药物活性与肿瘤抑制率均有提高。碳纳米管结合免疫治疗类药物和核酸还可从免疫学和基因水平治疗肿瘤。

关键词: 纳米管, 碳, 药物载体, 肿瘤治疗方案

Abstract: Targeted therapy means transporting drugs to certain tissue, aiming at increasing the utilization of drugs as well as reducing cytotoxicity. Chemotherapy drugs carried by carbon nanotube have high pharmaceutical activity and tumor control rate, compared with drugs alone. Carbon nanotube combined with immunotherapy drugs and nucleic acid can treat tumors at immunology and gene level.

Key words: Nanotubes, carbon, Drug carriers, Antineoplastic protocols