国际肿瘤学杂志

国际肿瘤学杂志 ›› 2019, Vol. 46 ›› Issue (4): 216-220.doi: 10.3760/cma.j.issn.1673-422X.2019.04.005

• 论著 • 上一篇    下一篇

血清胎盘钙黏素水平预测非小细胞肺癌患者预后的研究

马军1,罗居东2,景文江1,张淑莲1,王娟毅1,范志刚1   

  1. 1陕西省汉中三二〇一医院肿瘤科  723000； 2南京医科大学附属常州第二人民医院肿瘤中心，常州  213164
  • 收稿日期:2018-09-29 修回日期:2019-01-20 出版日期:2019-04-08 发布日期:2019-05-29
  • 通讯作者: 范志刚，Email: fanzg0418@163.com E-mail:fanzg0418@163.com

Prognostic value of serum P-cadherin level in patients with nonsmall cell lung cancer

Ma Jun1, Luo Judong2, Jing Wenjiang1, Zhang Shulian1, Wang Juanyi1, Fan Zhigang1   

  1. 1Department of Oncology, Hanzhong 3201 Hospital of Shaanxi Province, Hanzhong 723000, China; 2Tumor Center, Changzhou Second People′s Hospital Affiliated to Nanjing Medical University, Changzhou 213164, China
  • Received:2018-09-29 Revised:2019-01-20 Online:2019-04-08 Published:2019-05-29
  • Contact: Fan Zhigang, Email: fanzg0418@163.com E-mail:fanzg0418@163.com

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摘要： 目的  探讨血清胎盘钙黏素（P-cad）水平对非小细胞肺癌（NSCLC）患者预后的预测价值。方法  选择2012年1月至2013年12月在陕西省汉中三二〇一医院接受治疗的NSCLC患者80例作为研究对象，分析NSCLC患者中血清P-cad水平与临床病理特征的关系。采用Cox回归分析影响NSCLC患者预后的危险性因素。采用Kaplan-Meier法进行生存曲线绘制，用log-rank法进行差异性检验。结果  不同血清P-cad水平的NSCLC患者在淋巴结转移（χ2=14.31，P＜0.001）、血管浸润（χ2=5.56，P=0.018）方面差异有统计学意义。多因素Cox回归分析结果显示，淋巴结转移（HR=0.856，95%CI为0.702~0.955，P=0.012）、TNM分期（ⅢA：HR=1.315，95%CI为1.058~1.991，P=0.024；ⅢB：HR=1.448，95%CI为1.124~2.215，P=0.011；Ⅳ：HR=1.569，95%CI为1.182~2.441，P＜0.001）、高血清P-cad水平（HR=1.815，95%CI为1.224~3.562，P<0.001）是影响NSCLC患者无进展生存期的危险因素；淋巴结转移（HR=0.755，95%CI为0.652~0.915，P=0.022）、低分化（HR=1.622，95%CI为1.112~2.015，P<0.001）、TNM分期（ⅢA：HR=1.335，95%CI为1.064~2.014，P=0.011；ⅢB：HR=1.489，95%CI为1.129~2.297，P<0.001；Ⅳ：HR=1.622，95%CI为1.192~2.501，P<0.001）、高血清P-cad水平（HR=1.677，95%CI为1.193~2.668，P<0.001）是影响NSCLC患者总生存期的危险因素。Kaplan-Meier法生存曲线结果显示，血清P-cad高水平组患者总体生存期及无进展生存期均短于血清P-cad低水平组患者，差异有统计学意义（χ2=5.18，P=0.015；χ2=5.48，P=0.011）。结论  NSCLC患者中高血清P-cad水平与NSCLC患者不良预后密切相关。

关键词: 癌, 非小细胞肺, 钙黏着糖蛋白类, 淋巴结

Abstract: Objective  To investigate the prognostic value of serum P-cadherin (P-cad) level in patients with non-small cell lung cancer (NSCLC). Methods  A total of 80 patients with NSCLC in Hanzhong 3201 Hospital of Shaanxi Province from January 2012 to December 2013 were selected as study subjects. The relationships between serum P-cad level and clinicopathological characteristics were analyzed. The Cox regression analysis was used to analyze the risk factors affecting prognosis of NSCLC patients. The survival curve was drawn by Kaplan-Meier method and the difference test was carried out by log-rank method. Results  There were significant differences in lymph node metastasis (χ2=14.31, P＜0.001), vascular invasion (χ2=5.56, P=0.018) among NSCLC patients with different levels of serum P-cad. Multivariate Cox regression analysis showed that lymph node metastasis (HR=0.856, 95%CI: 0.702-0.955,P=0.012), TNM stage (ⅢA HR=1.315, 95%CI: 1.058-1.991, P=0.024; ⅢB HR=1.448, 95%CI: 1.124-2.215, P=0.011; Ⅳ HR=1.569, 95%CI: 1.182-2.441, P＜0.001) and high level of serum P-cad (HR=1.815, 95%CI: 1.224-3.562, P<0.001) were risk factors for progression-free survival in NSCLC patients, and lymph node metastasis (HR=0.755, 95%CI: 0.652-0.915, P=0.022), poor differentiation (HR=1.622, 95%CI: 1.112-2.015, P<0.001), TNM stage (ⅢA HR=1.335, 95%CI: 1.064-2.014, P=0.011; ⅢB HR=1.489, 95%CI: 1.129-2.297, P<0.001; Ⅳ HR=1.622, 95%CI: 1.192-2.501, P<0.001) and high level of serum P-cad (HR=1.677, 95%CI: 1.193-2.668, P<0.001) were risk factors for overall survival of NSCLC patients. The results of Kaplan-Meier survival curve showed that the overall survival and progression-free survival of patients with high level of serum P-cad were shorter than those of patients with low level of serum P-cad (χ2=5.18, P=0.015; χ2=5.48, P=0.011). Conclusion  High level of serum P-cad is closely related to poor prognosis in NSCLC patients.

Key words: Carcinoma, non-small-cell lung, Cadherins, Lymph nodes