国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (3): 209-211.doi: 10.3760/cma.j.issn.1673-422X.2014.03.015

• 综述 • 上一篇    下一篇

Maspin基因与胃癌侵袭转移

梁海鹏, 杨庆伟   

  1. 745000 甘肃省庆阳市人民医院肿瘤外科
  • 出版日期:2014-03-08 发布日期:2014-03-17
  • 通讯作者: 梁海鹏,E-mail: qylhp@126.com E-mail:qylhp@126.com

Maspin gene and the invasion and metastasis of gastric cancer

LIANG  Hai-Peng, YANG  Qing-Wei   

  1. Department of Oncological Surgery, Qingyang People’s Hospital of Gansu Province, Qingyang 745000, China
  • Online:2014-03-08 Published:2014-03-17
  • Contact: Liang Haipeng, E-mail: qylhp@126.com E-mail:qylhp@126.com

摘要: Maspin基因是从乳腺上皮细胞中分离出的抑癌基因,属于丝氨酸蛋白酶抑制剂超家族的成员。Maspin基因在胃癌侵袭和转移过程中发挥重要作用。研究表明,Maspin基因主要通过诱导肿瘤细胞凋亡、抑制肿瘤血管生成、甲基化修饰作用以及通过促进同质黏附、抑制异质黏附等方式来抑制胃癌的发生、发展和转移。

关键词: Maspin基因, 胃肿瘤, 肿瘤侵润, 肿瘤转移

Abstract: The maspin gene, a tumor suppressor gene and a member of the serpin superfamily, is isolated from mammary epithelial cells. Maspin gene plays an important role in the process of invasion and metastasis of gastric cancer. Researches show that maspin gene suppresses the occurrence, development and metastasis of gastric cancer mainly by inducing tumor cell apoptosis, inhibiting tumor angiogenesis, methylation modification, promoting homogeneity adhesion and inhibiting heterogeneous adhesion

Key words: Maspin gene, Stomach neoplasms, Neoplasm invasiveness, Neoplasm metastasis