国际肿瘤学杂志

国际肿瘤学杂志 ›› 2016, Vol. 43 ›› Issue (7): 495-498.doi: 10.3760/cma.j.issn.1673422X.2016.07.004

• 论著 • 上一篇    下一篇

CYP2E1基因多态性与客家人群胃癌易感性的研究

李涛, 赖春凤, 丘波, 邹浩元, 杨宇辉   

  1. 嘉应学院医学院病理学与病理生理学教研室
  • 出版日期:2016-07-08 发布日期:2016-06-03
  • 基金资助:

    广东省科技计划（2011B031800395）；广东省梅州市科技计划（2010B62）

Relationship between CYP2E1 genetic polymorphism and susceptibility of gastric cancer in Hakkaness

LI  Tao, LAI  Chun-Feng, QIU  Bo, ZOU  Hao-Yuan, YANG  Yu-Hui   

  1. *Department of Pathology and Pathophysiology, Medical College of Jiaying University, Meizhou 514031, China
  • Online:2016-07-08 Published:2016-06-03
  • Supported by:

    Science and Technology Plan Project of Guangdong (2011B031800395); Science and Technology Plan Project of Guangdong Meizhou (2010B62)

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摘要： 目的通过研究细胞色素P450 2E1（CYP2E1）基因多态性位点rs2031920与客家人群胃癌遗传易感性的相关性，探讨遗传和环境因素在胃癌发病中的作用。方法采取病例对照研究，选择经胃镜和病理检查确诊的梅州地区客家人群51例胃癌患者(胃癌组)和52例正常对照（对照组），对CYP2E1 rs2031920（C1053T）位点进行基因型及等位基因检测，分析其在两组间的分布特征。结果CYP2E1 rs2031920位点在梅州地区客家人群中存在CC、CT、TT多态性，各基因型在胃癌组的分布频率为62.75%（32/51）、33.33%（17/51）、3.92%（2/51），在对照组的分布频率为59.62%（31/52）、34.61%（18/52）、5.77%（3/52），两组之间的差异无统计学意义(χ2=0.235，P=0.889)。CYP2E1基因rs2031920位点的等位基因C、T在胃癌组和对照组构成比分别为79.41%（81/102）、20.59%（21/102）和76.92%（80/104）、23.08%（24/104），差异无统计学意义(χ2=0.186，P=0.666)。经性别、年龄分层分析结果显示也无统计学意义（χ2=4.412，P=0.129；χ2=0.898，P=0.473）。结论CYP2E1的基因多态性位点rs2031920与客家人群胃癌的易感性不相关。

关键词: 细胞色素P450, CYP2E1, 胃肿瘤, 多态性, 单核苷酸, 客家人群

Abstract: ObjectiveThrough the research of the relationship between cytochrome P450 2E1 (CYP2E1) rs2031920 genetic polymorphism and susceptibility of gastric cancer in Hakkaness to explore the role of genetic and environmental factors in gastric cancer. MethodsA casecontrol study was performed with the molecular epidemiological methods. A total of 51 gastric cancer cases (as the gastric cancer group) and 52 healthy people (as the control group) confirmed by pathology were selected from Hakkaness in Meizhou area. The genotypes and alleles of CYP2E1 rs2031920 (C1053T) in both of the above groups were detected, and then the distribution characteristics between the two groups were analyzed. ResultsThree genotypes CC, TC and TT of rs2031920(C1053T) were found in Hakkaness in Meizhou area. The distribution frequencies of CC, TC and TT genotypes were 62.75% (32/51), 33.33% (17/51) and 3.92% (2/51) in the gastric cancer group respectively, meanwhile, 59.62% (31/52), 34.61% (18/52) and 5.77% (3/52) in control group respectively. The difference between the two groups has no statistical significance (χ2=0.235, P=0.889). The distribution frequencies of CYP2E1 rs2031920 alleles (including C and T) were 79.41% (81/102) and 20.59% (21/102) in the gastric cancer group respectively, meanwhile,76.92% (80/104) and 23.08% (24/104) in the control group respectively, which also showed no significant difference between the two groups (χ2=0.186, P=0.666). And stratified analysis such as sex, age showed no significant results (χ2=4.412, P=0.129; χ2=0.898, P=0.473). ConclusionThe genetic polymorphisms of CYP2E1 rs2031920 is possibly not related with the susceptibility of gastric cancer in Hakkaness in Meizhou area.

Key words: Cytochrome P, 450 CYP2E1, Stomach neoplasms, Polymorphism, single nucleotide, Hakkaness