国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (4): 294-296.doi: 10.3760/cma.j.issn.1673422X.2014.04.017

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DNA甲基化及其在肾癌诊治中的应用

林少坤, 辛军, 许嵘, 欧阳永娥, 陈一峰, 郑锦阳, 辛明华, 陈光富   

  1. 362000 泉州，福建医科大学附属泉州第一医院泌尿外科（林少坤、辛军、欧阳永娥、陈一峰、郑锦阳、辛明华）；泉州医学高等专科学校药学系（许嵘）；解放军总医院泌尿外科（陈光富）
  • 出版日期:2014-04-08 发布日期:2014-03-17
  • 通讯作者: 辛军 E-mail:xinjun0595@163.com
  • 基金资助:

    泉州市科技项目（2013Z52）

DNA methylation and its application in the diagnosis and treatment of renal carcinoma

LIN  Shao-Kun, XIN  Jun, XU  Rong,Ouyang-Yong-E , CHEN  Yi-Feng, ZHENG  Jin-Yang, XIN  Ming-Hua, CHEN  Guang-Fu   

  1. Department of Urology, Affiliated Quanzhou First Hospital of Fujian Medical University, Quanzhou 362000, China
  • Online:2014-04-08 Published:2014-03-17
  • Contact: Xin Jun E-mail:xinjun0595@163.com

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摘要： 研究表明，肿瘤相关基因启动子区域的异常甲基化是引发肾癌的重要原因之一，并与肿瘤的分化、侵袭、转移、分期和预后等密切相关。检测相关抑癌基因甲基化有助于肾癌的早期诊断。甲基转移酶抑制剂可逆转肿瘤细胞的异常甲基化，并可增加其他化疗药物的疗效，在肾癌的治疗中起重要作用。

关键词: DNA甲基化, 肾肿瘤, 基因表达

Abstract: Researches show that the tumor related gene promoter methylation is an important reason of renal cancer and is closely associated with the differentiation, invasion, metastasis, staging and prognosis of tumor. Methylation detection of related tumor suppressor genes is helpful in early diagnosis of renal cancer. Methyltransferase inhibitors can reverse abnormal methylation of tumor cells, increase the curative effect of other chemotherapy drugs and play an important role in the treatment of renal cancer.

Key words: DNA methylation, Kidney neoplasms, Gene expression