Journal of International Oncology ›› 2022, Vol. 49 ›› Issue (7): 420-424.doi: 10.3760/cma.j.cn371439-20220429-00080

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Research status of glioblastoma-associated microglia

Fei Wenjing1, Wang Wenbao2, Xie Huanhuan3, Yan Jing2, Yang Mi1,2()   

  1. 1. Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing 210008, China
    2. Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China
    3. Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China
  • Received:2022-04-29 Revised:2022-06-07 Online:2022-07-08 Published:2022-09-19
  • Contact: Yang Mi E-mail:yangmi@nju.edu.cn

Abstract:

Microglia differ from macrophages with unique origin and role. In glioblastoma, microglia plays an important role in regulating tumor immune status, promoting tumor angiogenesis, destroying the blood-brain barrier, and reducing the sensitivity of treatment. Therefore, the combination of microglial therapy in the radiotherapy, chemotherapy and immunotherapy of glioblastoma has also become a clinically promising treatment.

Key words: Brain neoplasms, Immunomodulation