Journal of International Oncology ›› 2021, Vol. 48 ›› Issue (4): 225-230.doi: 10.3760/cma.j.cn371439-20200722-00045

• Reviews • Previous Articles     Next Articles

m6A methylation modification and lung cancer

Wu Hansheng1,2,3, Huang Shujie2,4, Zhuang Weitao2,4, Ding Yu2,3, Gao Zhen2,3, Qiao Guibin2,3,4()   

  1. 1Department of Thoracic Surgery, First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China
    2Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510000, China
    3Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
    4Department of Clinical Medicine, Shantou University Medical College, Shantou 515031, China
  • Received:2020-07-22 Revised:2020-12-07 Online:2021-04-08 Published:2021-06-18
  • Contact: Qiao Guibin E-mail:guibinqiao@126.com
  • Supported by:
    Construction of Key Laboratory of Lung Cancer Transforming Medicine in Guangdong Province(2017B030314120)

Abstract:

The biological role of N6-methyladenine (m6A) methylation modification has been gradually identified, and it has shown increasing value in tumor. In recent years, with the accumulated explore of epigenetics in RNA modification, many studies have reported that m6A methylation modification contributes to development and progression of lung cancer. m6A-related modified regulator has potential application value as a clinical target for diagnosis and treatment of lung cancer.

Key words: Lung neoplasms, m6A, RNA methylation