Abstract: The development of nonsmall cell lung cancer (NSCLC) is a complex process which referring to multifactor interaction. In this process, p53 gene regulates the normal growth of cells, but p53 gene after mutation can induce the occurrence of NSCLC, promote tumor distant metastasis, induce chemotherapy resistance, and cause poor prognosis of patients. Therefore, the restoration of normal expression of p53 gene is very significant for the treatment of NSCLC. In recent years, the rapid progress of p53 gene therapy has opened up a new way for the treatment of NSCLC.

Key words: Carcinoma, non-small-cell lung, Genes, p53, Therapeutic uses