Abstract: Thalidomide has antitumor effects such as antitumor angiogenesis, improvement of immune function and cachexia of patients with advanced tumors, which has been effectively used in elderly patients with castrationresistant prostate cancer, chemotherapy resistant advanced colorectal cancer, advanced hepatocellular carcinoma and metastatic breast cancer. As the indepth study of the antitumor mechanism of thalidomide, more and more clinical researches have focused on the function of thalidomide on nonhematological malignancies, especially it has obtained some achivements in the postoperative adjuvant therapy for highrisk colorectal cancer and primary hepatocellular carcinoma and the salvage therapy for metastatic triplenegative breast cancer and refractory gynecological tumor.

Key words: Neoplasms, Therapeutic uses, Thalidomide