Abstract: In order to make a rational and effective cure measure for lung cancer, we need to establish suitable animal model. Spontaneous or induced model needs long time to form tumor and the rate is not steady. Xenograft mouse model is widely used in laboratories because of its steady tumor formation rate and less time in oncogenesis. Engineered mouse model which is based on genetic technology not only helps us to understand pathological process of lung cancer, but also can provide an ideal preclinical model of targeted therapy experiment, and it will be the important development direction of lung cancer animal model.

Key words: Lung neoplasms, Models, animal