Abstract: Stromal cell types of the neoplastic microenvironment play important roles in the occurrence and development of tumor. Tumor-associated fibroblasts (TAFs) are the most abundant cells in tumor stroma.They promote the malignant transformation of epithelial cells and other cells through cell-cell communication via various soluble factors.

Key words: color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: AR-SA, mso-fareast-font-family: 宋体, mso-font-kerning: 1.0pt">Angiogenesis inhibitors, color: black, font-family: "Times New Roman", mso-ansi-language: EN-US, mso-fareast-language: ZH-CN, mso-bidi-language: HE, mso-fareast-font-family: 宋体">Tumor-associated fibroblast