Abstract: The invasion and metastasis of esophageal carcinoma is associated with several tumor marker on   oncogenesi and tumor development, including matrix metalloproteinase, cell adhesion molecules CD44,pituitary-tumour transforming genes.Studies have shown that these tumor markera are over-expression in esophageal carcinoma, which affect the progress and prognosis of esophageal carcinoma , and their specificity and value for clinical application need to be futher studied