国际肿瘤学杂志

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (7): 518-520.doi: 10.3760/cma.j.issn.1673422X.2014.07.011

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炎症反应与微小RNA差异性表达在肺癌中的研究进展

金东旭, 赵光强, 黄云超, 李虎   

  1. 650000 昆明医科大学研究生部（金东旭、李虎）；昆明医科大学第三附属医院胸外一科（赵光强、黄云超）
  • 出版日期:2014-08-04 发布日期:2014-08-04
  • 通讯作者: 黄云超，Email: huangych2001@yahoo.com.cn E-mail:huangych2001@yahoo.com.cn
  • 基金资助:

    国家自然科学基金（U1202224）

The research on inflammatory reaction and differential expression of microRNAs in lung caner

JIN  Dong-Xu, ZHAO  Guang-Qiang, HUANG  Yun-Chao, LI  Hu   

  1. *Graduate School of Kunming Medical University, Kunming 650000, China
  • Online:2014-08-04 Published:2014-08-04
  • Contact: Huang Yunchao E-mail:huangych2001@yahoo.com.cn

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被引次数

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摘要： 微小RNA（miRNA）是一类单链非编码RNA，直接与靶基因mRNA互补结合导致靶分子mRNA翻译受到抑制以降低靶基因的表达，参与细胞的分化、增殖、凋亡等过程。miRNA既参与调节炎症反应，也在肿瘤的形成中发挥重要作用。炎症反应与miRNA相互作用导致miRNA差异性表达引起肺癌的研究受到广泛关注。炎症反应与miRNA差异性表达机制研究的不断深入，有望给肺癌的预防、诊断及治疗带来新的策略。

关键词: 肺肿瘤, 全身炎症反应综合征, 微RNAs, STAT3转录因子, NF&kappa, B

Abstract: MicroRNA is a type of singlestranded noncoding RNA，directly bonding to the complementary target gene mRNA. That leads to the inhibition of mRNA translation of the target molecule in order to reduce expression of the target gene. MicroRNAs are not only involved in the regulation of inflammatory reaction, but also play important roles in the formation of neoplasm. The researches showing that the inflammatory reaction interacting with miRNAs results in the differential expressions of microRNAs in lung cancer have been widespreadly concerned. Along with the deepening of the research on the mechanisms of inflammatory reaction and differential expression of microRNAs， it will provide new strategies for the prevention, diagnosis and treatment of lung cancer.

Key words: Lung neoplasms, Systemic inflammatory response syndrome, MicroRNAs, STAT3 transcription factor, NFκB