人8-羟基鸟嘌呤DNA糖苷酶1与肺癌

doi:10.3760/cma.j.issn.1673-422X.2014.05.007

国际肿瘤学杂志 ›› 2014, Vol. 41 ›› Issue (5): 341-344.doi: 10.3760/cma.j.issn.1673-422X.2014.05.007

人8-羟基鸟嘌呤DNA糖苷酶1与肺癌

宾流,林子英,杨拉维,刘刚

524001湛江，广东医学院附属医院呼吸内科

收稿日期:2013-12-25 修回日期:2014-01-14 出版日期:2014-05-08 发布日期:2014-04-28
通讯作者: 刘刚 E-mail:gangliu11@gdmc.edu.cn
基金资助:
国家自然科学基金（81172615）

Human 8-oxoguanine DNA glycosylase and lung cancer

Bin Liu, Lin Ziying, Yang Lawei, Liu Gang

Department of Respiratory Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China

Received:2013-12-25 Revised:2014-01-14 Online:2014-05-08 Published:2014-04-28
Contact: Liu Gang E-mail:gangliu11@gdmc.edu.cn

摘要/Abstract

摘要： 人8-羟基鸟嘌呤DNA糖苷酶1（hOGG1）功能异常与肺癌等癌症发生发展密切相关，hOGG1基因多态性可能会改变酶的活性，从而影响个体损伤DNA的修复能力，促进癌变。hOGG1等DNA修复基因单核苷酸多态性联合效应提高人群肺癌的易感性。hOGG1参与调节肿瘤细胞的线粒体呼吸功能并影响肿瘤细胞生长。

关键词: 肺肿瘤, DNA, 线粒体, 人8-羟基鸟嘌呤DNA糖苷酶1

Abstract: Dysfunction of the human 8oxoguanine DNA glycosylase (hOGG1) is closely related to development of lung neoplasms and other cancers. Polymorphisms in hOGG1 gene may alter glycosylase activity, thereby affect its repair capacity to the damaged DNA, contributing to carcinogenesis. Joint effects of hOGG1 and other DNA repair gene SNPs have showed complex genegene interactions may significantly contribute to people′s lung cancer susceptibility. HOGG1 plays an important role in maintaining mitochondrial respiration thus affects tumor cell growth.

Key words: Lung neoplasms, DNA, mitochondrial, hOGG1

宾流,林子英,杨拉维,刘刚. 人8-羟基鸟嘌呤DNA糖苷酶1与肺癌[J]. 国际肿瘤学杂志, 2014, 41(5): 341-344.

Bin Liu, Lin Ziying, Yang Lawei, Liu Gang. Human 8-oxoguanine DNA glycosylase and lung cancer[J]. Journal of International Oncology, 2014, 41(5): 341-344.

参考文献

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人8-羟基鸟嘌呤DNA糖苷酶1与肺癌

Human 8-oxoguanine DNA glycosylase and lung cancer

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