国际肿瘤学杂志

国际肿瘤学杂志 ›› 2013, Vol. 40 ›› Issue (10): 758-761.

• 综述 • 上一篇    下一篇

肺癌动物模型

刘军, 靳晶, 崔淑香   

  1. 250062 济南，山东省医学科学院药物研究所药理室济南大学山东省医学科学院医学与生命科学学院 山东省罕少见病重点实验室（刘军、崔淑香）；山东大学药学院（靳晶）
  • 出版日期:2013-10-08 发布日期:2013-09-23
  • 通讯作者: 崔淑香，E-mail: sxccui@sina.com E-mail:sxccui@sina.com
  • 基金资助:

    国家自然科学基金（81072665）

Animal models of lung cancer

LIU  Jun, JIN  Jing, CUI  Shu-Xiang   

  1.  
    Department of Pharmacology, Institute of Materia Medica, Shandong Academy of Medical Sciences; School of Medicine and Life Sciences, University of Ji’nan-Shandong Academy of Medical Sciences; Key Laboratory for Rare Disease of Shandong Province, Ji’nan 250062,[1]China
  • Online:2013-10-08 Published:2013-09-23
  • Contact: CUI Shu-xiang, E-mail: sxccui@sina.com E-mail:sxccui@sina.com

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摘要： 研究制定合理有效的肺癌治疗措施，需要建立合适的动物模型。自发或由致癌物诱发的肺癌模型所需成瘤时间长，成瘤率不能保证；移植瘤模型成瘤率稳定且所需成瘤时间较短被实验室广泛运用；基于基因技术的转基因小鼠肺肿瘤模型，不仅有利于肺癌病理过程的理解，而且能提供理想的靶向治疗实验的临床前模型，将成为肺癌动物模型的重要发展方向。

关键词: 肺肿瘤, 模型, 动物

Abstract: In order to make a rational and effective cure measure for lung cancer, we need to establish suitable animal model. Spontaneous or induced model needs long time to form tumor and the rate is not steady. Xenograft mouse model is widely used in laboratories because of its steady tumor formation rate and less time in oncogenesis. Engineered mouse model which is based on genetic technology not only helps us to understand pathological process of lung cancer, but also can provide an ideal preclinical model of targeted therapy experiment, and it will be the important development direction of lung cancer animal model.

Key words: Lung neoplasms, Models, animal